Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & ISI's SCI  
Users online: 2104  
Home | Subscribe | Feedback | Login 
About Latest Articles Back-Issues Article Submission Resources Sections Etcetera Contact
 
  NAVIGATE Here 
 ::   Next article
 ::   Previous article
 ::   Table of Contents

 RESOURCE Links
 ::   Similar in PUBMED
 ::  Search Pubmed for
 ::  Search in Google Scholar for
 ::   Citation Manager
 ::   Access Statistics
 ::   Reader Comments
 ::   Email Alert *
 ::   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1420    
    Printed89    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal


 

 ARTICLE
Year : 1976  |  Volume : 22  |  Issue : 4  |  Page : 161-170

Studies on the mechanism of hypotensive action of a disubstituted piperazine derivative - (Part II)


Department of Pharmacology, Seth G. S. Medical College, Parel, Bombay-400012, India

Correspondence Address:
N K Dadkar
Hoechst Research Centre, Mulund, Bombay-400080.
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 1032831

Rights and PermissionsRights and Permissions

The mechanism of hypotensive action of R-1230, a new disub­stituted piperazine derivative was studied in anaesthetised normo­tensive cats. Rapid intravenous injection of R-1230 produced an immediate transient fall in blood pressure attributable to a direct peripheral vasodilator action as concluded from cat's hindquarters' perfusion experiment. The prolonged secondary hypotensive re­sponse appeared to be of complex nature. Inhibition of centrally mediated pressor reflexes on intracerebroventricular administra­tion, accompanied by peripheral adrenergic blockade, points to the dual mechanism of drug induced hypotension. Results in decere­brate and spinal preparations indicated the lower brainstem region lo be the principal site of central hypotensive action.






[FULL TEXT] [PDF Not available]*


        
Print this article     Email this article

Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow