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 ARTICLE
Year : 1978  |  Volume : 24  |  Issue : 3  |  Page : 177-181

Pharmacological Studies of p, N-(3, 4-Methylenedioxy Phenyl) Benzoic Acid (RRL-1364) - part-II


Department of Pharmacology, Seth G.S.Medical College, Parel, Bombay 400012, India

Correspondence Address:
Sharadini A Dahanukar
Department of Pharmacology, Seth G.S.Medical College, Parel, Bombay 400012
India
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Source of Support: None, Conflict of Interest: None


PMID: 722615

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Cholinomimetic activity of p, N- (3, 4-methylene dioxy phenyl) benzoic acid was revealed while studying its hypotensive activity in cats. Further evaluation of this activity showed that this com­pound had both muscarinic and nicotinic components. The cholino­mimetic activity was not similar to anticholinesterase like activity. Species variation was present; in rats it failed to show any activity and no activity was exhibited in vitro suggesting some metabolic transformation.






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Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow