Journal of Postgraduate Medicine
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 ARTICLE
Year : 1979  |  Volume : 25  |  Issue : 3  |  Page : 147-153

An experimental investigation to correlate changes in plasma fibrinolytic activity with isoprenaline induced myocardial damage


Department of Pharmacology, L.L.R.M, Medical College, Meerut-250102, India

Correspondence Address:
K K Saxena
Department of Pharmacology, L.L.R.M, Medical College, Meerut-250102
India
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Source of Support: None, Conflict of Interest: None


PMID: 529166

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Administration of different doses of isoprenaline in albino rats produced varying grades of myocardial necrosis with concomitant changes in euglobulin clot lysis time which is a measure of plasma fibrinolytic activity (PFA). A positive and strong correlation was observed between changes in PFA and severity of myocardial necrosis. Experiments in young rats and propranolol pre-treated animals rule out the possibility of isoprenaline being responsible in bringing about changes in PFA. The measurement of PFA appears to be of prognostic significance in myocardial infarction as discussed.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow