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  IN THIS Article
 ::  Introduction
 ::  Material and methods
 ::  Results
 ::  Discussion
 ::  References

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Year : 1981  |  Volume : 27  |  Issue : 2  |  Page : 105-8

Fibrinolytic activity in coronary heart disease.







How to cite this article:
Rani M M, Nath K K, Mehrotra T N, Mishra S D. Fibrinolytic activity in coronary heart disease. J Postgrad Med 1981;27:105


How to cite this URL:
Rani M M, Nath K K, Mehrotra T N, Mishra S D. Fibrinolytic activity in coronary heart disease. J Postgrad Med [serial online] 1981 [cited 2019 Dec 15];27:105. Available from: http://www.jpgmonline.com/text.asp?1981/27/2/105/5653




  ::   Introduction Top

Literature available on fibrinolytic activity in coronary heart disease presents conflicting reports. Some investigators[3], [4], [6], [8] have reported a greater incidence of low fibrinolytic activity in acute myocardial infarction while others[5], [7] could not show any effect on fibrinolytic activity in coronary heart disease. Therefore investigations of the relationship between fibrinolytic activity and coronary heart disease have been incomplete and inconclusive and require further confirmation. Present study was undertaken to find out the fibrinolytic activity in patients of coronary heart disease.

  ::   Material and methods Top

The study was carried out in two groups. Group A comprised of 25 healthy adults or patients suffering from diseases not usually regarded as affecting the fibrinolytic activity, serving as controls. Group B consisted of 83 cases of coronary heart disease (WHO criteria, 1961) admitted in the Medical Wards of S.V.B.P. Hospital, Meerut. Particular care was taken to exclude any other condition which might affect the fibrinolytic activity e.g. diabetes mellitus, renal disorders, cerebral thrombosis, neoplastic disease, hepatic disorders and rheumatoid arthritis. Smoking and tobacco were not allowed and physical activity, diet and time of meals were kept uniform during the study in both the groups.
Group B was further divided into two subgroups. Group B1 comprising of 83 cases of myocardial infarction (old or recent) and Group B3 consisted of 50 cases of coronary heart disease other than myocardial infarction (angina, acute coronary insufficiency). Of the 33 cases of myocardial infarction 13 were having complications like heart failure, arrhythmias, shock; the rest 20 cases were without complications; in group B2 only 8 cases were having complications.
Fibrinolytic activity was measured as Euglobulin clot lysis time (E.L.T.) (Buckell, 1958)2 in all cases on the 1st day, 2nd day, 3rd day and then weekly for 3 weeks in addition to E.C.G. and other routine biochemical tests."Z" test was applied to determine the level of significance of results and p was calculated from these Z values.


  ::   Results Top

Mean age for both the groups was 53 years and 53.8 years respectively and male to female ratio was 5:1. Fibrinolytic activity was found to be independent of the age and sex.
Mean E.L.T. in the control group was found to be 156.92 + 48.3 minutes while in group B it was 175.41 + 66.1 minutes [Table - 1] which was more than group A but statistically non-significant.
There was no significant change in the fibrinolytic activity even on the 2nd day, 3rd day and upto 3 weeks of infarction [Table - 2].
An attempt was also made to evaluate the difference in results between cases of myocardial infarction with complications and without complications. It was found that there was statistically significant fall in the fibrinolytic activity (Rise in. ELT) in cases of myocardial infarction with complications but not in cases of MI without complications [Table - 3].
When results of Group B2 were compared with controls, it was found that there was no significant fall in the fibrinolytic activity [Table - 4].

  ::   Discussion Top

Various risk factors have been blamed for causation of coronary heart disease. Decreased fibrinolytic activity has been thought to be one of the aetiological factors. Opinions about fibrinolytic activity in coronary heart disease have been conflicting. Generally a marked decrease in fibrinolytic activity has been reported in acute myocardial infarction[1], [3], [4], [6], [8] while others[9] have shown initial increase for a few hours and then a subsequent fall in the fibrinolytic activity in cases of myocardial infarction. In our study however there was no significant fall in the fibrinolytic activity in coronary heart disease either on the same day or even upto 3 weeks except in cases of myocardial infarction with complications in which fibrinolytic activity was significantly low on the 1st day and came to control level from 2nd day onwards. This finding makes us to think that the cases of coronary heart disease in whom fibrinolytic activity is significantly low, are more likely to develop complications. However this would require further confirmation with other controlled studies.

  ::   References Top

1.Bick, R. L., Bishop, R. C. and Shanbrom, E. S.: Fibrinolytic activity in acute myocardial infarction. Amer. J. Clin. Path., 57: 359-363, 1972.  Back to cited text no. 1    
2.Buckell, M.: Effect of citrate on euglobulin methods of, estimating fibrinolytic activity. J. Clin. Path., 11: 403-405, 1958.  Back to cited text no. 2    
3.Chakrabarti, R., Hocking, E., Fearnley, G., Mann, R. D., Atwell, T. N. and Jackson, D.: Fibrinolytic activity and coronary heart disease. Lancet, 1: 967-990, 1968.  Back to cited text no. 3    
4.Hume, R.: Fibrinolysis in myocardial infarction. Brit. Heart J., 20: 15-20, 1958.   Back to cited text no. 4    
5.Katz, A. M., McDonald, L., Davis, B. and Edgill, M.: Fibrinolysis and blood coagulation in ischaemic heart disease. Lancet, 1: 801-802, 1963.  Back to cited text no. 5    
6.Lackner, H. and Merskey, S.: Variation in fibrinolytic activity after acute myocardial infarction and after anticoagulants. Brit. J. Haematol., 6: 402-413, 1960.  Back to cited text no. 6    
7.Merskey, S., Gordon, H., Lackner, H., Schrire, V., Kaplon, B. J . , Sougin-Mibashen, R. Nossel H. L. and Moodie, A.: Blood coagulation and fibrinolysis in relation to coronary artery disease. Brit. Med. J., 1: 219-227, 1960.  Back to cited text no. 7    
8.Mittal, M. M., Gupta, N. N. and Mehrotra, R. M. L.: Study of plasma fibrinogen and fibrinolytic activity in myocardial infarction. J. Assoc. Phys. India, 18: 795-801, 1970.  Back to cited text no. 8    
9.Ogston, D. and Fullerton, H. W.: Plasma fibrinolytic activity following recent myocardial and cerebral infarction. Lancet, 2: 99-101, 1965.  Back to cited text no. 9    

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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow