Journal of Postgraduate Medicine
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Year : 1992  |  Volume : 38  |  Issue : 4  |  Page : 164-6

A comparative study of flurbiprofen and piroxicam in osteoarthritis.

Gandhi Medical College, Bhopal, Madhya Pradesh.

Correspondence Address:
N P Misra
Gandhi Medical College, Bhopal, Madhya Pradesh.

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Source of Support: None, Conflict of Interest: None

PMID: 0001307585

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In this single-blind, multiple-dose study the efficacy and tolerability of flurbiprofen was compared with that of piroxicam in 60 adult patients suffering from osteoarthritis of the knee. The patients were randomly allocated to receive either flurbiprofen 100 mg twice daily or piroxicam 20 mg once daily for a period of four weeks. Clinical assessments w.r.t. pain, tenderness, stiffness, swelling and general activity of patient were carried out prior to initiation of trial therapy and thereafter at weekly intervals for four weeks. The findings were graded. Though significant improvements as compared to baseline data occurred in both the treatment groups, flurbiprofen was found to be superior to piroxicam in improving pain on movement and at rest (p < 0.05). The incidence of side effects was less in the group receiving flurbiprofen (6% compared to 47% observed with piroxicam).

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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow