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Year : 1993  |  Volume : 39  |  Issue : 2  |  Page : 63-7

An evaluation of serum and tissue bound immunoglobulins in prostatic diseases.

Dept of Surgery, Government Medical College, Nagpur, Maharashtra.,

Correspondence Address:
D R Gahankari
Dept of Surgery, Government Medical College, Nagpur, Maharashtra.

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Source of Support: None, Conflict of Interest: None

PMID: 0007513363

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In forty-four patients with different prostatic lesions serum immunoglobulins and tissue deposited immunoglobulins were studied by single radial immunodiffusion technique, and direct immunofluorescence and immunoperoxidase (PAP) methods respectively. Serum IgM levels were found reduced only in patients with prostatic carcinomas (80% of cases) as compared to controls. Serum IgA levels showed stage dependence in prostatic carcinoma being more raised in advanced malignancy (stage C and D) than in localized ones (stage B). Localization of immunoglobulins particularly IgM, was characteristically found in stroma and lumen along with intracellular localization in prostatic carcinoma; while normal and benign lesions of prostate only showed characteristic 'necklace' pattern. Also the intensity of deposits of immunoglobulins in poorly differentiated prostatic carcinomas was markedly low as compared to well differentiated carcinomas indicating lowered local immunological response in former. In prostatitis, IgA was also found localized in lumen indicating the immunological defence against infection by secretory antibody (IgA).


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow