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  IN THIS Article
 ::  Abstract
 ::  Introduction
 ::  Case report
 ::  Discussion
 ::  Acknowledgment
 ::  References

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CASE REPORT
Year : 1995  |  Volume : 41  |  Issue : 1  |  Page : 12-3

Detection of medullary carcinoma of thyroid, with liver metastasis, using 99mTc DMSA(V) scintigraphy.


Dept of Nuclear Medicine, K E M Hospital, Parel, Bombay.

Correspondence Address:
S Shikare
Dept of Nuclear Medicine, K E M Hospital, Parel, Bombay.

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Source of Support: None, Conflict of Interest: None


PMID: 0010740693

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 :: Abstract 

A sixty year old female referred for thyroid and liver scintigraphy had a clinical history of progressive swelling in the neck with hepatomegaly. A large cold area was detected in the right thyroid lobe using 99mTc pertechnetate and in the right lobe of liver using 99mTc phytate. Subsequent whole body scan with 99mTC DMSA(V) showed avid tracer uptake in right lobe of thyroid and liver. Aspiration cytology of thyroid and liver showed medullary carcinoma of thyroid with its metastasis in liver. Histopathology following thyroidectomy confirmed the diagnosis. Thus 99mTc pentavalent DMSA contributes specificity to diagnose medullary carcinoma of thyroid and metastatic lesions.


Keywords: Carcinoma, Medullary, radionuclide imaging,secondary,Case Report, Female, Human, Liver Neoplasms, radionuclide imaging,secondary,Middle Age, Sodium Pertechnetate Tc 99m, diagnostic use,Technetium Tc 99m Dimercaptosuccinic Acid, diagnostic use,Thyroid Neoplasms, pathology,radionuclide imaging,


How to cite this article:
Shikare S, Bashir K, Menon P S, Bapat R D, Tilve G H. Detection of medullary carcinoma of thyroid, with liver metastasis, using 99mTc DMSA(V) scintigraphy. J Postgrad Med 1995;41:12

How to cite this URL:
Shikare S, Bashir K, Menon P S, Bapat R D, Tilve G H. Detection of medullary carcinoma of thyroid, with liver metastasis, using 99mTc DMSA(V) scintigraphy. J Postgrad Med [serial online] 1995 [cited 2019 Nov 13];41:12. Available from: http://www.jpgmonline.com/text.asp?1995/41/1/12/477





  ::   Introduction Top


Medullary carcinoma of the thyroid is an uncommon tumour arising from the parafollicular cells of the thyroid[1]. The major sites of distant metastasis of this tumour are lung, liver and bone 99m Tc labelled pentavalent DMSA has been shown to be taken Op by the primary and recurrent tumour, along with its metastasis, with sensitivity variably reported as 65 to 88%[2]. We present the case report of a patient who had medullary carcinoma of the thyroid with metastasis in the liver.


  ::   Case report Top


A sixty-year-old female referred for thyroid and liver scintigraphy had a clinical history of progressive swelling in the neck along with hepatomegaly. Biochemical, thyroid function tests were normal but serum calcitonin levels were raised.

Thyroid scan done with 99m Tc pertechnetate revealed a large cold area in the centre of the enlarged right lobe [Figure:1] and 99m Tc phytate liver scan showed a large cold area in the right lobe of liver posterolaterally [Figure:2].

Subsequent whole body scan with 99m Tc DMSA (V) showed (1) avid tracer uptake in the right lobe with central area of decreased tracer uptake, (2) Intense focal tracer accumulation in the right lobe of liver posterolaterally, correspondingly with the lesion seen on the routine liver scan [Figure:3]. No skeletal metastases were seen.

Aspiration cytology from the thyroid and the liver showed medullary carcinoma of thyroid and its metastasis in the liver. Subsequently, the patient underwent thyroidectomy and histopathology confirmed the diagnosis of medullary carcinoma of thyroid.


  ::   Discussion Top


In patients of medullary carcinoma of the thyroid (a) 99m Tc pertechnetate imaging of the thyroid demonstrates an area of reduced uptake corresponding to the site of the nodule that is solid on ultrasound. (b) liver-spleen scans demonstrate areas of reduced tracer uptake in the sites of metastasis and (c) bone metastasis are picked up as areas of increased tracer uptake on bone scan. However, all these findings are non-specific as other pathological states can give rise to such scan findings.

99m Tc pentavalent DMSA is selectively taken up into sites of primary, recurrent and metastatic medullary carcinoma of the thyroid. Due to its remarkably low, non-specific uptake in organs such as the liver and bone marrow, identification of liver and bone metastases is facilitated[3]. This greatly increases the specificity of the diagnosis of medullary carcinoma of thyroid in suspected primary, recurrent and metastatic sites. Thus this imaging agent is now contributing significantly to patient management with its ability to define both local soft tissue recurrence and distant metastasis.


  ::   Acknowledgment Top


We thank the Dean, Seth GS Medical College and King Edward Memorial Hospital for allowing us to publish these data.

 
 :: References Top

1. Clarke SEM, MaisY MN, Briton KE, Gildy DL. Tumour imaging in Clinical Nuclear Medicine, 2nd ed. 1991; 434-435.  Back to cited text no. 1    
2.Clarke SEM, Lazarus C, Wraight P. Pentavalent 99m Tc DIVISA, 131 MIBG and 99m Tc MDP, an evaluation of three imaging techniques in patients with medullary carcinoma thyroid. J Nucl Med 1988; 29:33-38.  Back to cited text no. 2    
3.Jojnson DG, Coleman RE, McCook TA, Dale JK, Wells SA Bone and liver images in medullary carcinoma of the thyroid gland. Concise communication. J Nucl Med 1984; 25:419-422.   Back to cited text no. 3    



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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
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