Journal of Postgraduate Medicine
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Year : 1995  |  Volume : 41  |  Issue : 3  |  Page : 64-5

Roxatidine in duodenal ulcer.


Dept of Gastroenterology, Osmania Medical College, Osmania General Hospital, Hyderabad.

Correspondence Address:
C M Habibullah
Dept of Gastroenterology, Osmania Medical College, Osmania General Hospital, Hyderabad.

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Source of Support: None, Conflict of Interest: None


PMID: 0010707717

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Roxatidine acetate is a new H2-receptor antagonist. A randomized double-blind clinical trial in fifty-three patients with endoscopically proven duodenal ulcers > 5 mm in diameter was undertaken to compare safety and efficacy of roxatidine with that of ranitidine. Twenty-six patients received roxatidine (75 mg bid) while 27 patients received ranitidine (150 mg bid) for 4 weeks. One patient in each group did not come for follow up. Roxatidine and ranitidine had comparable ulcer healing rates (22/25 vs 22/26); roxatidine, however, resulted in greater reduction in the number and severity of night time pain episodes (p < 0.05). No adverse event was reported during 4 weeks of treatment with roxatidine. Thus roxatidine achieves the primary therapeutic goal of relief of pain better than ranitidine.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow