Journal of Postgraduate Medicine
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 ORIGINAL ARTICLE
Year : 2000  |  Volume : 46  |  Issue : 3  |  Page : 172-5

Putrescine, DNA, RNA and protein contents in human uterine, breast and rectal cancer.


Department of Medicine, University College of Medicine, Dr. B. C. Roy Postgraduate Institute of Basic Medical Sciences, Calcutta-700 020, India., India

Correspondence Address:
M Bandopadhyay
Department of Medicine, University College of Medicine, Dr. B. C. Roy Postgraduate Institute of Basic Medical Sciences, Calcutta-700 020, India.
India
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Source of Support: None, Conflict of Interest: None


PMID: 11298463

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AIMS: To find out the status of DNA, RNA and protein in human uterine, ovarian, breast and rectal carcinoma. MATERIAL AND METHODS: In this prospective study, patients of age group between late thirties and late fifties suffering from uterine, ovarian, breast and rectal cancer were taken as subjects of the present study. The total number of cases studied for each cases was ten. Pieces of human carcinomatous tissues of above mentioned cases were taken along with surrounding normal tissues. From the tissue samples, putrescine is separated by the method of Herbst et al, DNA analysed by Diphenylamine method, RNA by Orcinol method and protein by Biuret method. RESULTS: Tissue content of putrescine rises simultaneously with that of DNA, RNA and protein in carcinomatous growths as above in comparison to their respective adjacent normal tissue, the differences being statistically highly significant. CONCLUSIONS: Increase in DNA, RNA and protein concentration may be a pre-requisite for increased synthesis of putrescine in carcinomatous tissue and thereby the concentration of other di- and poly-amines.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow