Journal of Postgraduate Medicine
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 CASE REPORT
Year : 2000  |  Volume : 46  |  Issue : 3  |  Page : 181-3

Progressive systemic sclerosis (scleroderma), carcinoma breast and valvular heart disease: an unusual combination.


Department of Medicine, Govt. Medical College and S. M. H. S. Hospital, Srinagar, Jammu & Kashmir, India., India

Correspondence Address:
M S Dewani
Department of Medicine, Govt. Medical College and S. M. H. S. Hospital, Srinagar, Jammu & Kashmir, India.
India
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Source of Support: None, Conflict of Interest: None


PMID: 11298466

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Systemic sclerosis is a multi system disorder characterised by fibrosis of skin and internal organs. There are reports of relation between cancer and polymyositis/dermatomyositis, but no overall association with systemic sclerosis. Reports of the coexistence of cancer and systemic sclerosis, however, emphasise a close temporal relation in their occurrence. Cardiac involvement in the form of myocardial fibrosis and pericarditis occurs frequently in systemic sclerosis, while valvular involvement has been reported only sporadically. We report a patient, admitted for adenocarcinoma of left breast who was found to have features of systemic sclerosis, pulmonary hypertension, gangrene of toes, and stenotic mitral valve disease. The possible mechanisms of the coincidence of the three disorders are discussed.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow