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CASE REPORT
Year : 2002  |  Volume : 48  |  Issue : 1  |  Page : 29-31

Primary pleuro-pulmonary malignant germ cell tumours.


Department of Pathology, Seth G. S. Medical College, Mumbai - 400 012, India., India

Correspondence Address:
P Vaideeswar
Department of Pathology, Seth G. S. Medical College, Mumbai - 400 012, India.
India
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Source of Support: None, Conflict of Interest: None


PMID: 12082324

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 :: Abstract 

Lungs and pleura are rare sites for malignant germ-cell tumours. Two cases, pure yolk-sac tumour and yolk sac-sac tumour/embryonal carcinoma are described in young males who presented with rapid progression of respiratory symptoms. The malignant mixed germ cell tumour occurred in the right lung, while the yolk-sac tumour had a pseudomesotheliomatous growth pattern suggesting a pleural origin. Alpha-foetoprotein was immunohistochemically demonstrated in both.


Keywords: Adolescent, Adult, Case Report, Endodermal Sinus Tumor, pathology,Fatal Outcome, Human, Lung Neoplasms, pathology,Male, Pleural Neoplasms, pathology,alpha-Fetoproteins, analysis,


How to cite this article:
Vaideeswar P, Deshpande J R, Jambhekar N A. Primary pleuro-pulmonary malignant germ cell tumours. J Postgrad Med 2002;48:29-31

How to cite this URL:
Vaideeswar P, Deshpande J R, Jambhekar N A. Primary pleuro-pulmonary malignant germ cell tumours. J Postgrad Med [serial online] 2002 [cited 2019 May 20];48:29-31. Available from: http://www.jpgmonline.com/text.asp?2002/48/1/29/158


Extragonadal germ cell tumours are rare lesions and are mainly located in the retroperitoneal, mediastinal, pineal and presacral regions.[1],[2] Lungs and pleura are extremely uncommon sites for such tumours. We report two cases of malignant germ cell tumours in young males.


  ::   Case history Top


Case 1

A 14-year-old male presented with low-grade fever, cough with mucoid expectoration and progressive breathlessness for the 15 days. On examination, the boy was febrile with tachycardia and respiratory distress. The trachea was shifted to the right with left-sided dull percussion note and decreased vocal resonance. The clinical impression was of left pleural effusion with collapse of the left lung, probably tuberculosis. Chest radiography revealed diffuse opacification of the left side. Undifferentiated small round cells were seen on fine-needle aspiration cytology. However, the child died before further investigations could be carried out.

A complete autopsy was performed. The heart weighed 60 gm. and was normal. The whole of the left pleural cavity was occupied by a highly mucoid, lobulated, soft, necrotic grey white mass completely encasing the left lung in a mesotheliomatous pattern [Figure - 1]. Apart from collapse, the left lung parenchyma was normal. There was no intrabronchial or parenchymal tumour. The right lung was normal. No tumour was seen in the testes, retroperitoneum, mediastinum and other organs.

The tumour, on histology, showed features of a yolk-sac tumour with microcystic and papillary patterns. The tumour cells had moderate amounts of pink cytoplasm and mildly pleomorphic nuclei with coarsely clumped chromatin. The intervening stroma was loose and myxoid. Intracytoplasmic and extra cellular PAS-positive, diastase resistant hyaline droplets were frequently seen. Immunohistochemistry for alpha-foetoprotein was strongly positive [Figure - 2]. No other germ cell elements were identified in the tumour or in any other organ, including the testes. Hence a diagnosis of primary pleural yolk-sac tumour was made.

Case 2

A 20 year-old-male had a rapidly progressive dyspnoea with associated fever, cough, chest pain, anorexia and weight-loss for the past one month. The clinical impression was tuberculosis. The haematological and biochemical parameters were within normal limits. Computed tomographic scan of the chest revealed a well-defined, heterogeneous mass in the upper zone of the right lung with minimal right pleural and pericardial effusions. The patient expired within two days of admission.

At autopsy, the right and middle lobes were voluminous and wholly occupied by a large (13x12x12 cm), well circumscribed, tan-coloured necrotic tumour [Figure - 3]. The pleura overlying the tumour was markedly thickened, opacified and adherent to the parietal pericardium. In addition, there were two smaller nodules, grey white to light brown in colour, in the anterior and posterior basal segments of the right lower lobe. The right hilar and carinal lymph nodes were enlarged, grey white and necrotic.

Multiple sections from the tumour and lymph nodes showed necroses and haemorrhage with a peripheral rim of viable tumour cells. The cells were largely in sheets with moderate to abundant eosinophilic to clear cytoplasm and extremely pleomorphic nuclei. Bizarre forms and giant cells were scattered throughout [Figure - 4]. However, in some areas, the cells showed papillary and glandular pattern with loose textured stroma [Figure - 5]. The cells were found to be focally positive for cytokeratin and strongly positive for alpha-foetoprotein;human chorionic gonadotrophin (HCG), and placental alkaline phosphatase were negative. The

impression was of an embryonal carcinoma with yolk-sac tumour of the lung. Primary germ cell tumour elsewhere was ruled out.

The left lung had multiple fresh haemorrhagic infarcts due to occlusive pulmonary arterial thrombi. The cause of death was attributed to acute thrombosis of the dominant right coronary artery and acute myocardial infarction.


  ::   Discussion Top


A diagnosis of a malignant extragonadal germ cell tumour can be established if the criteria laid by Einhorn[3] are fulfilled. They include absence of a detectable (including stigmata of burnt-out lesion) or subsequent appearance of a gonadal tumour and absence of nodal metastases in the para-aortic and iliac regions. With these stringent criteria, the lung emerges as an extremely uncommon site for such tumours. Most of them have been mixed germ-cell tumours. In an early study by Holt et al,[4] 20 teratomatous tumours were found to involve the thoracic region. Seven among these were excluded because of probable mediastinal location. Thirteen had primary pulmonary location and five of these were malignant. In a recent review by Miller et al[5] and Pont et al,[6] 30 cases of germ cell tumours and about 12 cases of malignant tumours, respectively, were reported. Histologically, these tumours have been teratoma with embryonal carcinoma and yolk-sac tumour components[4],[5],[7],[8] or teratomas with malignant transformation[4] or embryonal carcinoma mixed with yolk-sac tumour[2] or seminoma.[6],[9] Inoue and associates have reported pure yolk-sac tumour of the lung once.[10] In the present report, one was a pure yolk-sac tumour while the other was combined with embryonal carcinoma.

There is a general agreement that these tumours occur in the younger age group, grow rapidly, are large and necrotic and associated with elevated levels of alpha-foetoprotein and HCG. All the cases were located within the lungs as was seen in case 2. However, a pleural yolk-sac tumour encasing the lung in a mesotheliomatous pattern with compression of the lung has never been reported. Both the cases were strongly positive for alpha-foetoprotein immunohistochemically, Serum levels were not estimated, as a clinical diagnosis of germ cell tumour was not entertained. In fact, Richardson and group designated such tumours as “unrecognised extragonadal germ cell cancer syndrome.”[11] They studied 12 patients diagnosed as poorly differentiated or large cell undifferentiated carcinomas. Lung was involved in six patients;isolated lung involvement was not present. There was no detailed pathologic description.

Recognising such lung tumours in patients is important because these tumours are sensitive to chemotherapy with increased patient survival. At the same time, such tumours should not be over-diagnosed especially in the elderly since non-germ cell epithelial malignancies can also produce alpha-foetoprotein.[2],[12]

 
 :: References Top

1.Aparicio J, Montalar J, Munarriz EB, Reynes G, Gomez-Codina J, Pastor M, et al. Extragondal germ cell tumors:Prognostic factors and long term follow up. European Urol 1995;28:19-24.  Back to cited text no. 1    
2.Hunter S, Hewman-Lowe K, Costa MJ. Primary pulmonary alpha-fetoprotein-producing malignant germ cell tumor. Hum Pathol 1990;21:1074-6.  Back to cited text no. 2    
3.Einhorn LH. Extragonadal germ cell tumors. In: Einhorn LH, editor. Testicular tumors. New York: Masson Publishing; 1980:185-204.  Back to cited text no. 3    
4.Holt S, Deverall PB, Boddy JE. A teratoma of the lung containing thymic tissue. J Pathol 1978;126: 85-9.  Back to cited text no. 4    
5.Miller RR, Champagne K, Murray RC. Primary pulmonary germ cell tumor with blastomatous differentiation. Chest 1994;106:1595-6.  Back to cited text no. 5    
6.Pont J, Pridun N, Vesely N, Kienzer HR, Pont E, Spital FJ. Extragonadal malignant germ cell tumor of the lung. J Thorac Cardiovasc Surg 1994;107:311-2.  Back to cited text no. 6    
7.Kuhn MW, Weissbach L. Localization, incidence, diagnosis and treatment of extratesticular germ cell tumors. Urol Int 1985;40:166-72.  Back to cited text no. 7    
8.Stair JM, Stevenson DR, Schaffer RF, Fullenwider JP. Primary teratocarcinoma of the lung. J Surg Oncol 1986;33:262-7.  Back to cited text no. 8    
9.Feun LG, Samson MK, Stephens RL. Vinblastine (VLB), Bleomycin(BLEO), Cis-diamine dichloroplatinum (DDP) in disseminated extragonadal germ cell tumors. A southwest oncology group study. Cancer 1980;45:2543-9.  Back to cited text no. 9    
10.Inoue H, Iwasaki M, Ogawa J, et al. Pure yolk-sac tumor of the lung. Thorac Cardiovasc Surg 1993;41:249-51.  Back to cited text no. 10    
11.Richardson RL, Schoumacher RA, Fer MR, Hande KR, Forbes JT, Oldham RK, et al. The unrecognized extragonadal germ cell syndrome. Ann Intern Med 1981;94:181-6.  Back to cited text no. 11    
12.Orkunaka T, Kato H, Konaka C, Yamamoto H, Furukawa K. Primary lung cancer producing alpha-fetoprotein. Ann Thorac Surg 1992;53:151-2.  Back to cited text no. 12    


    Figures

[Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4], [Figure - 5]

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