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LETTER TO EDITOR
Year : 2004  |  Volume : 50  |  Issue : 4  |  Page : 310-311

Carcinoma prostate presenting as pleural effusion with metastatic pleural mass


Department of Pathology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi-110 060, India

Correspondence Address:
Atul Gogia
Department of Pathology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi-110 060
India
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Source of Support: None, Conflict of Interest: None


PMID: 15623982

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How to cite this article:
Gogia A, Agarwal P K, Vasdev N, Sachar V P. Carcinoma prostate presenting as pleural effusion with metastatic pleural mass . J Postgrad Med 2004;50:310-1

How to cite this URL:
Gogia A, Agarwal P K, Vasdev N, Sachar V P. Carcinoma prostate presenting as pleural effusion with metastatic pleural mass . J Postgrad Med [serial online] 2004 [cited 2019 Nov 17];50:310-1. Available from: http://www.jpgmonline.com/text.asp?2004/50/4/310/13659


Sir,



A 49-year-old male, presented with dry cough for three weeks. He was febrile for ten days and was breathless for two days. He also gave history of urinary hesitancy (off and on) for the past four months. He was tachypnoeic (RR-23/min), febrile (38 C) with clinical features suggestive of right-sided pleural effusion. A clinical diagnosis of infective right-sided pleural effusion was made.



Chest radiograph showed right-sided pleural effusion with suspicious parenchymal mass in the right lower lung zone. Right-sided intercostal tube drained two litres of haemorrhagic fluid. The pleural fluid had a glucose concentration of 168 mg/dl, total protein concentration of 5.8 gm/dl and albumin level of 3.3 mg/dl. On microscopic examination the fluid demonstrated presence of 65 cells per cubic mm. These were predominantly lymphocytes. No organisms or malignant cells were seen. A contrast CT scan thorax revealed thickened pleura with nodular appearances. A CT guided fine needle aspiration of the pleural nodule was done. A diagnosis of malignant mesothelioma was offered initially. In the hospital, the patient developed retention of urine. Per rectal examination revealed a hard nodular prostate. USG abdomen showed cholelithiasis, multiple calcific foci in the spleen and dense calcification in the prostate with residual urine of 260 cc. Uroflowmetry showed bladder outflow tract obstruction. PSA levels were high (62.3). Prostatic biopsy revealed poorly differentiated prostatic carcinoma showing positivity for PSA on immunohistochemistry. On reassessing the pleural biopsy in the presence of prostatic carcinoma, the pleural lesion was thought to be metastatic rather than primary although PSA staining was negative on the pleural tissue. Bone scan revealed a suspicious area in the left intertrochanteric area. A final diagnosis of poorly differentiated prostatic cancer with metastatic pleural disease and bone metastasis was made. The patient was given chemotherapy along with flutamide. A bilateral orchidectomy was done. He was advised regular follow-up. Clinical and radiological improvement was seen at the time of the six months follow-up.



Prostatic cancer is known for its varied patterns of dissemination. Pulmonary metastases from prostatic carcinoma are common; however, the nodular lesions readily identified on thoracic roentgenograms are usually asymptomatic.[1] A previous review showed that pulmonary metastases from prostate adenocarcinoma are found at autopsy in 25% to 38% of patients but are evident on chest films in only 5.5% to 6.7%.[2] Intrathoracic involvement of metastatic adenocarcinoma of the prostate may appear on roentgenograms as parenchymal nodules (84%), mediastinal adenopathy (12%) or lymphatic spread (4%);[2] pleural involvement is the second rarest site after the adrenals among the soft tissue metastases.[3] Pulmonary secondaries secondary to prostrate carcinoma are amenable to anti-androgen therapy or orchidectomy with prolonged symptomatic remission.



Immunocytochemistry by PSA is a sensitive and specific method of detection of metastatic prostatic adenocarcinoma, but there have been case reports showing that it can be negative in some cases.[4] Therefore, it should not be taken as a confirmatory test.

 
 :: References Top

1.Lome LG, John T. Pulmonary manifestations of prostatic carcinoma. J Urol 1973;109:680-5.  Back to cited text no. 1    
2.Rockey KE, Graham TE. Prostatic Adenocarcinoma metastatic to the lung. Postgrad Med 1990;87:199-208.  Back to cited text no. 2    
3.Ansari MS, Nabi G, Seth A. Massive pleural effusion without Bony Involvement: An Unusual presentation of Advanced Carcinoma Prostate. Indian J Cancer 2002;39:123-4.  Back to cited text no. 3    
4.Renshaw AA, Granter SR. Metastatic, sarcomatoid, PSA-, and PAP- negative prostatic carcinoma: Diagnosis by fine needle aspiration. Diagn Cytopathol 2000;23:199-201.  Back to cited text no. 4    




 

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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow