Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & ISI's SCI  
Users online: 2338  
Home | Subscribe | Feedback | Login 
About Latest Articles Back-Issues Article Submission Resources Sections Etcetera Contact
 
  NAVIGATE Here 
  Search
 
 :: Next article
 :: Previous article 
 :: Table of Contents
  
 RESOURCE Links
 ::  Similar in PUBMED
 ::  Search Pubmed for
 ::  Search in Google Scholar for
 ::  Article in PDF (53 KB)
 ::  Citation Manager
 ::  Access Statistics
 ::  Reader Comments
 ::  Email Alert *
 ::  Add to My List *
* Registration required (free) 

  IN THIS Article

 Article Access Statistics
    Viewed2518    
    Printed89    
    Emailed0    
    PDF Downloaded118    
    Comments [Add]    

Recommend this journal


 


 
COMMENTARY
Year : 2005  |  Volume : 51  |  Issue : 5  |  Page : 4

A Fruitful Idea


City Hospital,Birmingham B18 7QH, United Kingdom

Correspondence Address:
R E Ferner
City Hospital,Birmingham B18 7QH
United Kingdom
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 16522957

Rights and PermissionsRights and Permissions




How to cite this article:
Ferner R E. A Fruitful Idea. J Postgrad Med 2005;51, Suppl S1:4

How to cite this URL:
Ferner R E. A Fruitful Idea. J Postgrad Med [serial online] 2005 [cited 2019 Jul 20];51, Suppl S1:4. Available from: http://www.jpgmonline.com/text.asp?2005/51/5/4/19807


Western pharmaceutical companies are beholden to their shareholders, and their shareholders expect profits. This skews drug development towards 'the diseases of the rich.' Most people in the world, however, live in poor countries where life expectancy and the quality of life are diminished by infectious diseases now rare in the Western world. Visceral leishmaniasis is one such disease. An affordable, safe, and effective treatment for kala azar would be of considerable benefit in endemic areas. Standard amphotericin has been used, but is far from ideal, because of systemic and renal adverse effects.

Liposomal therapy with amphotericin greatly reduces the incidence of systemic and renal adverse effects of the drug, but the standard commercial preparation is extremely expensive: a single day's treatment for an adult can easily cost over US$600.

It is rare for academic institutions to be responsible for the entire development of a new drug. The concept of an effective but affordable liposomal preparation, its careful investigation, and its development in animal models and then in human subjects is a signal achievement by the academic groups in Mumbai and their co-workers in Delhi, constrained as they were by limited resources. Patients with kala azar and serious fungal infections should be the beneficiaries.




 

Top
Print this article  Email this article
Previous article Next article
Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow