Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & ISI's SCI  
Users online: 83  
Home | Subscribe | Feedback | Login 
About Latest Articles Back-Issues Article Submission Resources Sections Etcetera Contact
 
  NAVIGATE Here 
  Search
 
 :: Next article
 :: Previous article 
 :: Table of Contents
  
 RESOURCE Links
 ::  Similar in PUBMED
 ::  Search Pubmed for
 ::  Search in Google Scholar for
 ::  Article in PDF (143 KB)
 ::  Citation Manager
 ::  Access Statistics
 ::  Reader Comments
 ::  Email Alert *
 ::  Add to My List *
* Registration required (free) 

  IN THIS Article
 ::  References
 ::  Article Figures

 Article Access Statistics
    Viewed4038    
    Printed74    
    Emailed1    
    PDF Downloaded150    
    Comments [Add]    
    Cited by others 1    

Recommend this journal


 


 
LETTER TO EDITOR
Year : 2006  |  Volume : 52  |  Issue : 1  |  Page : 71-72

An unusual lipomatous hemangiopericytoma


Department of Pathology, T. N. Medical College and B. Y. L. Nair Hospital, Dr. A. L. Nair Road, Mumbai Central, Mumbai-400008, India

Correspondence Address:
G P Amonkar
Department of Pathology, T. N. Medical College and B. Y. L. Nair Hospital, Dr. A. L. Nair Road, Mumbai Central, Mumbai-400008
India
Login to access the Email id


PMID: 16534175

Get Permissions




How to cite this article:
Amonkar G P, Deshpande J R, Kandalkar B M. An unusual lipomatous hemangiopericytoma. J Postgrad Med 2006;52:71-2

How to cite this URL:
Amonkar G P, Deshpande J R, Kandalkar B M. An unusual lipomatous hemangiopericytoma. J Postgrad Med [serial online] 2006 [cited 2014 Aug 22];52:71-2. Available from: http://www.jpgmonline.com/text.asp?2006/52/1/71/21658


Sir,

Lipomatous hemangiopericytoma is a very rare variant of hemangiopericytoma, which behaves in a benign fashion. It occurs in the lower extremity, thigh, and pelvic fossa.[1] Histologically, these are characterized by an admixture of benign hemangiopericytomatous areas with mature adipose tissue.[1] To date, very few cases have been reported in literature.[1],[2],[3],[4],[5] We report a case of this unusual, rare tumor in this paper.

A 39-year-old man came with a history of breathlessness since 1 year. A CT scan revealed a well-circumscribed heterogeneous mass containing fat located in the anterior mediastinum. The mass was surgically excised. On examination, it was well-circumscribed, measuring 6.5 4.5 4 cm 3; the cut section was solid and whitish with intermixed yellowish fatty areas. On histology, the tumor showed diffuse sheets of cells with distinct pericytic vascular pattern [Figure - 1]. There were multiple branching anastamosing small and large vascular channels, giving a stag-horn appearance. Large areas of mature adipose tissue were seen interspersed in between [Figure - 2]. Tumor cells were plump polygonal with bland nuclear features. No spindle cells were seen. On immunohistochemistry (IHC) CD34 (monoclonal, Dako) was negative. Considering the histomorphological features, a diagnosis of lipomatous hemangiopericytoma was made. The patient has been free of any recurrences or metastasis for over a year.

Stout and Murray in 1942 introduced the term "hemangiopericytoma" for tumors that were composed mainly of pericytes.[1] The diagnosis of hemangiopericytoma is based on the branching architectural pattern of small and large vessels. They occur during adult life, the common sites being thigh, pelvic fossa, and retroperitoneum.[1] There are histomorphological similarities between hemangiopericytoma and solitary fibrous tumor (SFT). SFT occurs in the pleura and other body cavities. They show focal pericytic pattern with spindling of cells, broad zones of hyalinization, and on IHC virtually all cases are CD34-positive.[1],[2]

A lipomatous hemangiopericytoma was first described in the German literature by Theunissen et al. in 1990.[2] In 1995, Nielson et al gave a detailed account of this tumor. Subsequently, more cases have been reported and few even at unusual sites such as head and neck.[5] Few authors even favor a unifying concept of lipomatous hemangiopericytoma and SFT.[3]

Our case had many unusual features. The site of occurrence of this tumor in the mediastinum is exceedingly rare.[1],[2],[3] To the best of our knowledge, only one more case has been described in the mediastinum.[3] CD34 negativity on IHC is also uncommon.[1],[2],[3] The closest differential diagnosis in our case is the SFT. But in our case, the architectural pattern was typical of lipomatous hemangiopericytoma and was present throughout the tumor. Spindling of the cells was not present.

Lipomatous hemangiopericytoma is an extremely unusual tumor. In some cases it may be mistaken for a well-differentiated liposarcoma.[4] Hence it is important to keep this entity in mind especially when only a small biopsy is available. Clinicoradiological features of a well-circumscribed mass and typical histology with lack of lipoblasts favor a diagnosis of lipomatous hemangiopericytoma.[1],[4]

 
 :: References Top

1.Weiss SW, Goldbum JR. Perivascular Tumors. In: Soft tissue tumors. Weiss SW, Goldbum JR, editors, Mosby; 2001. p. 985-1035.  Back to cited text no. 1    
2.Ceballos KM, Munk PL, Masri BA, O'Connell JX. Lipomatous haemangiopericytoma: A morphologically distinct soft tissue tumor. Arch Pathol Lab Med 1999;123:941- 5.   Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Guillou L, Gebhard S, Coindre JM, Lipomatous haemangiopericytoma: A fat containing variant of solitary fibrous tumor? Clinicopathologic, immunohistochemical and ultrastructural analysis of a series in favour of a unifying concept. Hum Pathol 2000;31:1108-15.  Back to cited text no. 3    
4.Folpe AL, Devaney K, Weiss SW. Lipomatous haemangiopericytoma - a rare variant of haemangiopericytoma that may be confused with liposarcoma. Am J Surg Pathol 1999;23:1201-7.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]
5.Alrawi SJ, Deeb G, Cheney R, Wallace P, Loree T, Rigual N, et al . Lipomatous haemangiopericytoma of the head and neck. Head Neck 2004;26:544-9.  Back to cited text no. 5    


    Figures

[Figure - 1], [Figure - 2]

This article has been cited by
1 Management of a retrorectal lipomatous hemangiopericytoma by preoperative vascular embolization and a multidisciplinary surgical team: Report of a case
Dozois, E.J., Malireddy, K.K., Bower, T.C., Stanson, A.W., Sim, F.H.
Diseases of the Colon and Rectum. 2009; 52(5): 1017-1020
[Pubmed]



 

Top
Print this article  Email this article
Previous article Next article
Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Medknow