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 ORIGINAL ARTICLE
Year : 2008  |  Volume : 54  |  Issue : 3  |  Page : 186-190

The application of C12 biochip in the diagnosis and monitoring of colorectal cancer: Systematic evaluation and suggestion for improvement


1 Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumour Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, 430 071, P. R, China
2 Department of Oncology, Central Hospital of Xian'ning City, Xian'ning, Hubei, 437 100, P. R, China

Correspondence Address:
Y Li
Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumour Biological Behaviors and Hubei Cancer Clinical Study Center, Wuhan, 430 071, P. R
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0022-3859.40963

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Background: The 12 tumor markers' (TMs) biochip diagnostic (C12) system has been proven useful in some previous studies but its value for colorectal cancer (CRC) only was not systematically investigated. Aims: To evaluate the value of C12 system for CRC. Settings and Design: The associations between TMs and clinicopathological characteristics were evaluated. The most relevant TMs, the most useful combinations, and the correlations between TM levels were assessed. Materials and Methods: The TMs detected by the C12 system in the sera of 170 pathologically confirmed CRC patients were analyzed. One or more TMs higher than or equal to reference value were defined as positive. Statistical Analysis: Chi-square test, Spearman rank correlation test and Receiver-operating characteristic (ROC) curves were used for the analysis. Results: The overall positive rate was 41.76%, and was low in stage 0-I (12.90%). Carcinoembryonic cantigen (CEA) had the highest positive rate of 36.47%. The positive rates were significantly correlated to clinical stages and lymph node status, but not to age, sex, tumor location and pathological types. Any combinations of the five highest positive TMs did not have significantly improvements. The levels of three most related TMs (CEA, CA19-9, CA242) of CRC had positive correlation with each other. CA242 and β-HCG levels were associated with lymph node metastasis. Conclusions: C12 system has some value in advanced CRC, but not in early CRC.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow