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 ADR REPORT
Year : 2008  |  Volume : 54  |  Issue : 4  |  Page : 332-334

Nicolau syndrome following intramuscular benzathine penicillin


Department of Surgery, Goa Medical College, Bambolim, Goa - 403 202, India

Correspondence Address:
R De Sousa
Department of Surgery, Goa Medical College, Bambolim, Goa - 403 202
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0022-3859.43523

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Nicolau syndrome (NS) is a rare complication of an intramuscular injection characterized by severe pain, skin discoloration, and varying levels of tissue necrosis. The case outcomes vary from atrophic ulcers and severe pain to sepsis and limb amputation. We describe a case of a seven-year-old boy with diagnosis of NS after intramuscular benzathine penicillin injection to the ventrolateral aspect of the left thigh. Characteristic violaceous discoloration of skin and immediate injection site pain identified it as a case of NS. The case was complicated by rapid progression of compartment syndrome of the lower limb, proceeding to acute renal failure and death. Associated compartment syndrome can be postulated as a poor prognostic factor for NS.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow