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 ORIGINAL ARTICLE
Year : 2009  |  Volume : 55  |  Issue : 3  |  Page : 161-164

Antiphospholipid antibodies in young Indian patients with stroke


1 Department of Pathology, Command Hospital, Southern Command, Pune - 411 040, India
2 Military Hospital, Cardiothoracic Centre, Pune - 411 040, India

Correspondence Address:
M N Mishra
Department of Pathology, Command Hospital, Southern Command, Pune - 411 040
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0022-3859.57387

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Background : Stroke may be caused by antiphospholipid antibodies (APL), especially in young persons without other risk factors. Aim : The aim of this study was to determine the prevalence of two clinically significant APL-anticardiolipin antibody (ACL) and lupus anticoagulants (LA) in young patients presenting with sudden neurological deficit. Settings and Design : A case-control study performed in a large tertiary care government hospital. Materials and Methods : Ten milliliters of blood was collected from 51 consecutive young patients (age less than 45 years) diagnosed as ischemic stroke and 50 healthy age- and sex-matched controls. Statistical Analysis : Statistical analysis was done using Epi Info TM 6 software. Results : Overall, the risk factor profile was: Smoking (23.5%), positive family history (13.7%), hyperlipidemia (8%), and diabetes mellitus (3.6%). APL (LA and ACL) were present in 29.4% of the samples and in 4% of controls. The 'P' value for ACL and LA was 0.03 and 0.02 respectively, but the maximum level of ACL was 25 GPL units only. One-fourth of the patients were smokers and one-sixth had a family history of thrombosis ( P = 0.048 and 0.036, respectively). Conclusions : APL, positive family history and smoking were significantly associated with stroke in the young. We advocate screening for APL in all young patients with stroke.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
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