Journal of Postgraduate Medicine
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 TECHNOLOGY REVIEW
Year : 2009  |  Volume : 55  |  Issue : 4  |  Page : 301-304

Structure-based drug design and modern medicine


Department of Medicine, Saint Vincent Hospital, Worcester, MA, USA

Correspondence Address:
R Vijayakrishnan
Department of Medicine, Saint Vincent Hospital, Worcester, MA
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0022-3859.58943

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Drug discovery has evolved through various stages into more rational and evidence-based drug designing. Compared to conventional methods which were time consuming and less logical, new drug designing based on structure is rational, evidence based, faster and more scientific in nature. In the era of modern medicine, where newer insights into molecular level of disease processes are available, it is very essential that drug designing be based on molecular mechanism of pathologic processes. Structure-based drug designing has made tremendous contributions in the field of cancer chemotherapy, drug resistant infections, neurological diseases, to mention a few. New drug discovery methods are furthered by developments in the technology especially computers, bioassay techniques and calibrated instruments. Computational structure-based drug designing opens the door to novel treatments in modern medicine.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow