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NEWS AND FILLER
Year : 2010  |  Volume : 56  |  Issue : 3  |  Page : 191

Discovery of valproate


Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai 400012, India

Date of Web Publication23-Aug-2010

Correspondence Address:
N Gogtay
Department of Clinical Pharmacology, Seth GS Medical College and KEM Hospital, Mumbai 400012
India
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Source of Support: None, Conflict of Interest: None


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How to cite this article:
Gogtay N. Discovery of valproate. J Postgrad Med 2010;56:191

How to cite this URL:
Gogtay N. Discovery of valproate. J Postgrad Med [serial online] 2010 [cited 2020 Jan 18];56:191. Available from: http://www.jpgmonline.com/text.asp?2010/56/3/191/68644


The anti-convulsant effect of sodium valproate was discovered serendipitously in 1962 by Pierre Emymard who was working on the effect of khelline derivatives for his thesis. At that time, valproate was being used as a vehicle by two of his colleagues, H Meunier and Y Meunier to dissolve water insoluble compounds. Eymard in his experiments found that the vehicle control (valproate alone) produced significant anti-epileptic effect in rats. Meunier who used valproate to dissolve coumarin also found similar results in rabbits. Their findings were published in the French journal Therapie in 1963 and the first formulation of valproate "Depakine" was launched in France in 1967, 5 years later by Berthier Labs for whom Meunier and Meunier worked.




 

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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow