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 REVIEW ARTICLE
Year : 2011  |  Volume : 57  |  Issue : 4  |  Page : 321-328

Statin intolerance: Now a solved problem


1 Department of Pharmacology, LLRM Medical College, Muradnagar, Ghaziabad, India
2 Department of Oral Pathology and Microbiology, ITS CDSR, Muradnagar, Ghaziabad, India
3 Department of Medicine, IDST, Meerut, Uttar Pradesh, India

Correspondence Address:
P Sikka
Department of Pharmacology, LLRM Medical College, Muradnagar, Ghaziabad
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0022-3859.90085

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Statins are the most effective and widely used drugs for treating dyslipidemia, a major risk factor for coronary heart disease. These are one of the safest hypolipidemic drugs but many patients are bound to discontinue statins due to their side effects. Hepatotoxicity, myotoxicity and peripheral neuropathy are important out of them. Discontinuation of statins leads to dylipidemia and its grave consequences. Hence, there should be enough strategies for statin intolerant patients, so that they can be saved from these consequences. These side effects can be avoided by the awareness of certain factors viz. potential drug interactions and dose adjustment according to patho-physiology of the patient. Baseline investigations for liver function and muscle toxicity should be done before initiating statin therapy. Here, we are discussing various options for statin intolerant hyperlipidemic patients such as lower and intermittent dosing of statins, alternate hypolipidemic drugs, red yeast rice, supplementation with coenzyme Q10 and vitamin D. A number of hypolipidemic drugs are in trial phases and hold promise for statin intolerant patients.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow