Journal of Postgraduate Medicine
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 CASE REPORT
Year : 2013  |  Volume : 59  |  Issue : 2  |  Page : 135-137

Diffusion weighted MR imaging of 5-fluorouracil and oxaliplatin-induced leukoencephalopathy


1 Department of Neurology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India
2 Intensive Care Unit, Dayanand Medical College and Hospital, Ludhiana, Punjab, India

Correspondence Address:
B S Paul
Department of Neurology, Dayanand Medical College and Hospital, Ludhiana, Punjab
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0022-3859.113845

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A 55-year-old man treated with 5-fluorouracil and oxaliplatin for advanced sigmoid colon cancer presented with seizures, progressive gait and balance difficulties with frequent falls and slurring of speech. After three cycles of chemotherapy, brain magnetic resonance imaging using diffusion-weighted imaging clearly revealed the presence of high signal intensity in the deep white matter of the bilateral cerebral hemispheres, including the corpus callosum symmetrically. A diagnosis of acute leukoencephalopathy was made based on these findings. His clinical symptoms normalized after the discontinuation of the chemotherapy. Early detection of drug-induced leukoencephalopathy is important as the clinical symptoms can be reversed by early discontinuation of the causative drug. Diffusion-weighted magnetic resonance imaging is a useful modality for the early detection and definitive diagnosis of this characteristic encephalopathy.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow