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 ORIGINAL ARTICLE
Year : 2014  |  Volume : 60  |  Issue : 3  |  Page : 248-253

Outcome of surgically treated octogenarians with breast cancer


Department of Breast Surgery, Russells Hall Hospital, Dudley, West Midlands, United Kingdom

Correspondence Address:
LHM Tan
Department of Breast Surgery, Russells Hall Hospital, Dudley, West Midlands
United Kingdom
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Source of Support: None, Conflict of Interest: None


PMID: 25121362

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Context: Breast cancer is the commonest cancer in women worldwide and its incidence increases with increasing age. In an era of evidence-based practice, there is a paucity of evidence relating to the management of breast cancer in an oncogeriatric population. The authors define oncogeriatrics as cancer in patients aged 80 years or more. Aim: The study aimed to evaluate the survival benefit of surgically managed octogenarians with breast cancer. Materials and Methods: This was a retrospective study of octogenarians diagnosed with breast cancer over a 5-year period and who were treated surgically. Kaplan-Meier survival analysis was used to determine the overall survival. The differences in survival were tested using the logrank (Mantel-Cox) test. A P-value of <0.05 was considered to be statistically significant. Results: One hundred patients were included (median age- 84 years, median follow up 3.3 years). A validated adult comorbidity evaluation-27 (ACE-27) index score system was used to characterize patient comorbidities. Fourteen percent of patients had severe comorbidities, 55% nonsevere, 11% no comorbidities, and 20% with unknown comorbidities. The estrogen receptor was positive in 67% of tumors. Eighty-four percent had mastectomy and 15% had wide local excision. Sixty-eight percent had axillary lymph node dissection, 10% had sentinel lymph node biopsy, and 5% had no axillary surgery. The majority (72%) of the tumors were pathologically T1 or T2 tumor. The Nottingham Prognostic Index (NPI) mean score was 4.4. The Kaplan-Meier survival analysis showed a median survival of 5 years. Forty-eight percent died during the observation period, with 54.2% of this group dying of causes unrelated to breast cancer. Conclusion: The surgically treated octogenarians in our sample had an acceptable survival outcome






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow