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 DRUG REVIEW
Year : 2014  |  Volume : 60  |  Issue : 3  |  Page : 300-302

Bedaquiline: A novel antitubercular drug for multidrug-resistant tuberculosis


Department of Pharmacology, Mandya Institute of Medical Sciences, Mandya, Karnataka, India

Correspondence Address:
Dr. H Nagabushan
Department of Pharmacology, Mandya Institute of Medical Sciences, Mandya, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0022-3859.138772

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Multidrug-resistant and extensively drug-resistant tuberculosis (TB) are emerging global health threats. Bedaquiline is a new antituberculous drug belonging to the diarylquinoline class that efficiently inhibits the adenosine triphosphate synthase enzyme of Mycobacterium tuberculosis. It is a bactericidal and long-acting drug. It inhibits both dormant as well as replicating bacterial sub-populations and thus shortens the duration of TB treatment. This drug has been approved by the Food and Drug Administration in December 2012 for the management of multidrug resistant-TB. The drug marks the introduction of a new addition to the TB armamentarium after four decades.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow