Journal of Postgraduate Medicine
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 ADVERSE DRUG REACTION REPORT
Year : 2015  |  Volume : 61  |  Issue : 2  |  Page : 110-111

Iatrogenic nocturnal eneuresis- an overlooked side effect of anti histamines?


1 Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
2 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy
3 Allergology and Immunology Unit, University of Messina, Messina, Italy

Correspondence Address:
R S Calabro
Allergology and Immunology Unit, University of Messina, Messina
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0022-3859.153105

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Nocturnal enuresis is a common disorder in childhood, but its pathophysiological mechanisms have not been fully elucidated. Iatrogenic nocturnal enuresis has been described following treatment with several psychotropic medications. Herein, we describe a 6-year-old child who experienced nocturnal enuresis during treatment with the antihistamine cetirizine. Drug rechallenge was positive. Several neurotransmitters are implicated in the pathogenesis of nocturnal enuresis, including noradrenaline, serotonin and dopamine. Antihistamine treatment may provoke functional imbalance of these pathways resulting in incontinence.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow