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  Table of Contents     
LETTER
Year : 2015  |  Volume : 61  |  Issue : 2  |  Page : 145

Authors' reply


Department of Pediatrics, Hematology and Oncology Unit, Hospital 12 Octubre, Madrid, Spain

Date of Web Publication13-Mar-2015

Correspondence Address:
L I Gonzalez-Granado
Department of Pediatrics, Hematology and Oncology Unit, Hospital 12 Octubre, Madrid
Spain
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Source of Support: None, Conflict of Interest: None


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How to cite this article:
Dominguez-Pinilla N, Baro-Fernandez M, Gonzalez-Granado L I. Authors' reply. J Postgrad Med 2015;61:145

How to cite this URL:
Dominguez-Pinilla N, Baro-Fernandez M, Gonzalez-Granado L I. Authors' reply. J Postgrad Med [serial online] 2015 [cited 2019 Nov 18];61:145. Available from: http://www.jpgmonline.com/text.asp?2015/61/2/145/153115


Sir,

We thank Chhabra P for their comments. [1] The HIV test in our patient returned negative (HIV tests during pregnancy were also negative). It has also been reported HLH in AIDS is secondary not to the virus itself, but to overwhelming infections (particularly Pneumocystis jiroveci and nontuberculous mycobacteria). Complex immune mechanisms in HIV-Leishmania have been reported elsewhere. [2] In our country comparison between different microbiological techniques has been reported. However, serology is neither sensitive nor specific in the general Spanish population [3] and in HIV patients. [4] Our data on file in a pediatric cohort of HLH-Leishmania patients shows that only 32% of patients had a positive urine test. Thus, in our country the most reliable test remains PCR in bone marrow samples, followed by PCR in peripheral blood.

 
 :: References Top

1.
Chhabra P. Offender: Virus or parasite or both. J Postgrad Med 2015;61:145.  Back to cited text no. 1
  Medknow Journal  
2.
Okwor I1, Uzonna JE. The immunology of Leishmania/HIV co-infection. Immunol Res. 2013 May; 56:163-71.   Back to cited text no. 2
    
3.
Cruz I1, Chicharro C, Nieto J, Bailo B, Cañavate C, Figueras MC. Comparison of new diagnostic tools for management of pediatric Mediterranean visceral leishmaniasis. J Clin Microbiol. 2006;44:2343-7.   Back to cited text no. 3
    
4.
García-García JA, Martín-Sánchez J, Gállego M, Rivero-Román A, Camacho A, Riera C et al. Use of noninvasive markers to detect Leishmania infection in asymptomatic human immunodeficiency virus-infected patients. J Clin Microbiol. 200;44:4455-8.  Back to cited text no. 4
    




 

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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
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