Journal of Postgraduate Medicine
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Year : 1979  |  Volume : 25  |  Issue : 3  |  Page : 147-153  

An experimental investigation to correlate changes in plasma fibrinolytic activity with isoprenaline induced myocardial damage

KK Saxena, B Gupta, VK Kulshrestha, DN Prasad 
 Department of Pharmacology, L.L.R.M, Medical College, Meerut-250102, India

Correspondence Address:
K K Saxena
Department of Pharmacology, L.L.R.M, Medical College, Meerut-250102
India

Administration of different doses of isoprenaline in albino rats produced varying grades of myocardial necrosis with concomitant changes in euglobulin clot lysis time which is a measure of plasma fibrinolytic activity (PFA). A positive and strong correlation was observed between changes in PFA and severity of myocardial necrosis. Experiments in young rats and propranolol pre-treated animals rule out the possibility of isoprenaline being responsible in bringing about changes in PFA. The measurement of PFA appears to be of prognostic significance in myocardial infarction as discussed.


How to cite this article:
Saxena K K, Gupta B, Kulshrestha V K, Prasad D N. An experimental investigation to correlate changes in plasma fibrinolytic activity with isoprenaline induced myocardial damage.J Postgrad Med 1979;25:147-153


How to cite this URL:
Saxena K K, Gupta B, Kulshrestha V K, Prasad D N. An experimental investigation to correlate changes in plasma fibrinolytic activity with isoprenaline induced myocardial damage. J Postgrad Med [serial online] 1979 [cited 2020 Feb 20 ];25:147-153
Available from: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1979;volume=25;issue=3;spage=147;epage=153;aulast=Saxena;type=0


 
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