Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & EMBASE  
     Home | Subscribe | Feedback  

SYMPOSIUM
[View FULLTEXT] [Download PDF
 
Year : 2005  |  Volume : 51  |  Issue : 3  |  Page : 210-214  

Leptospirosis vaccines: Past, present, and future

N Koizumi, H Watanabe 
 Department of Bacteriology, National Institute of Infectious Diseases 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan

Correspondence Address:
H Watanabe
1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640
Japan

It is well known that Leptospira vaccine prevents the disease. However specificity for serovars limits the efficacy of killed whole cell vaccines. Leptospiral antigens that induce cross-protective immunity to the various serovars are sought as new vaccine candidates. In this paper, we have summarized both past and current findings about leptospiral antigens that are conserved among pathogenic leptospires and that induce protective immunity in animal models. The full-length genome sequences of two Leptospira strains have been published and reverse vaccinology has been used to identify leptospiral vaccine candidates. Although humoral immunity is thought to be dominant in protection from leptospiral infection, a role for cell-mediated immunity is now being explored.


How to cite this article:
Koizumi N, Watanabe H. Leptospirosis vaccines: Past, present, and future.J Postgrad Med 2005;51:210-214


How to cite this URL:
Koizumi N, Watanabe H. Leptospirosis vaccines: Past, present, and future. J Postgrad Med [serial online] 2005 [cited 2020 Feb 20 ];51:210-214
Available from: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2005;volume=51;issue=3;spage=210;epage=214;aulast=Koizumi;type=0


 
Thursday, February 20, 2020
 Site Map | Home | Contact Us | Feedback | Copyright  and disclaimer