Journal of Postgraduate Medicine
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ORIGINAL ARTICLE
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Year : 2007  |  Volume : 53  |  Issue : 3  |  Page : 161-165  

Neostigmine does not prolong the duration of analgesia produced by caudal bupivacaine in children undergoing urethroplasty

N Bhardwaj, S Yaddanapudi, B Ghai, J Wig 
 Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012, India

Correspondence Address:
N Bhardwaj
Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
India

Context : Neostigmine extends the duration of analgesia produced by caudal bupivacaine in children. Aims : To study the effect of different doses of caudal neostigmine on the duration of postoperative analgesia. Settings and Design : A randomized, double-blind study was conducted in 120 boys aged 1-12 years undergoing urethroplasty under combined general and caudal anesthesia. Materials and Methods : Children were administered 1.875 mg/kg bupivacaine alone (Group B), or with 2, 3 or 4 g/kg of neostigmine (groups BN 2 , BN 3 or BN 4 respectively) as caudal drug (0.75 ml/kg). Children with a pain score of 4 or more (OPS and NRS) postoperatively were administered rescue analgesic. Time to first analgesic and the number of analgesic doses administered in the 24h were recorded. Statistical Analysis : Parametric data were analyzed using ANOVA. Kaplan-Meier survival curves for the time to first analgesic administration were plotted and compared using log rank analysis. Chi-square test was used to analyze the incidence data. Results : The median [IQR] time to first analgesic in Group B (540 [240-1441] min) was similar to that in Groups BN 2 (450 [240-720]), BN 3 (600 [360-1020]) and BN 4 (990 [420-1441]). Significantly more patients in Groups B (9 [34.6%]) and BN 4 (13 [44.8%]) required no supplemental analgesic for 24h than those in Groups BN 2 and BN 3 (4 [13.8%] and 4 [13.3%]). The number of analgesic doses required in 24h in the four groups was similar. Conclusion : Addition of neostigmine to 1.875 mg/kg of caudal bupivacaine did not prolong the analgesia following urethroplasty in children.


How to cite this article:
Bhardwaj N, Yaddanapudi S, Ghai B, Wig J. Neostigmine does not prolong the duration of analgesia produced by caudal bupivacaine in children undergoing urethroplasty.J Postgrad Med 2007;53:161-165


How to cite this URL:
Bhardwaj N, Yaddanapudi S, Ghai B, Wig J. Neostigmine does not prolong the duration of analgesia produced by caudal bupivacaine in children undergoing urethroplasty. J Postgrad Med [serial online] 2007 [cited 2020 May 27 ];53:161-165
Available from: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2007;volume=53;issue=3;spage=161;epage=165;aulast=Bhardwaj;type=0


 
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