Journal of Postgraduate Medicine
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Year : 2008  |  Volume : 54  |  Issue : 3  |  Page : 203-205  

Fungal encephalitis following bone marrow transplantation: Clinical findings and prognosis

HAG Teive1, ALM Carsten1, FM Iwamoto1, SM Almeida1, RP Munhoz1, LC Werneck1, CR Medeiros2, R Pasquini2 
1 Neurology Service, Department of Internal Medicine, Hospital de Clínicas, Federal University of Paraná, Curitiba, Pr, Brazil
2 Bone Marrow Transplantation Service, Department of Internal Medicine, Hospital de Clínicas, Federal University of Paraná, Curitiba, Pr, Brazil

Correspondence Address:
HAG Teive
Neurology Service, Department of Internal Medicine, Hospital de Clínicas, Federal University of Paraná, Curitiba, Pr
Brazil

Background: Central nervous system fungal infections (FI) are important complications and a cause of mortality in patients who receive hematopoietic stem cell transplantation (HSCT). Aims: To study the clinical aspects of fungal encephalitis (FE). Settings and Design: The study was carried out at the HSCT Center of the Hospital de Clνnicas, Federal University of Paranα, Curitiba, Brazil. Materials and Methods: Clinical records and autopsy reports from patients submitted to HSCT with a diagnosis of FE. Results: Twelve patients were diagnosed with FE presenting with lowered level of consciousness, hemiparesis and seizures. We were able to identify two subgroups regarding susceptibility to FE: (1) patients with early onset FI and severe leucopoenia, and (2) patients with later onset FI with graft-versus-host disease using immunosuppressive drugs. Eleven of the patients died directly due to the neurological complication, all had post-mortem confirmation of the diagnosis of FI. Conclusions: These clinical, paraclinical and temporal patterns may provide the opportunity for earlier diagnosis and interventions.


How to cite this article:
Teive H, Carsten A, Iwamoto F M, Almeida S M, Munhoz R P, Werneck L C, Medeiros C R, Pasquini R. Fungal encephalitis following bone marrow transplantation: Clinical findings and prognosis.J Postgrad Med 2008;54:203-205


How to cite this URL:
Teive H, Carsten A, Iwamoto F M, Almeida S M, Munhoz R P, Werneck L C, Medeiros C R, Pasquini R. Fungal encephalitis following bone marrow transplantation: Clinical findings and prognosis. J Postgrad Med [serial online] 2008 [cited 2019 Dec 12 ];54:203-205
Available from: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2008;volume=54;issue=3;spage=203;epage=205;aulast=Teive;type=0


 
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