Journal of Postgraduate Medicine
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Year : 2009  |  Volume : 55  |  Issue : 3  |  Page : 161-164  

Antiphospholipid antibodies in young Indian patients with stroke

MN Mishra1, S Rohatgi2 
1 Department of Pathology, Command Hospital, Southern Command, Pune - 411 040, India
2 Military Hospital, Cardiothoracic Centre, Pune - 411 040, India

Correspondence Address:
M N Mishra
Department of Pathology, Command Hospital, Southern Command, Pune - 411 040
India

Background : Stroke may be caused by antiphospholipid antibodies (APL), especially in young persons without other risk factors. Aim : The aim of this study was to determine the prevalence of two clinically significant APL-anticardiolipin antibody (ACL) and lupus anticoagulants (LA) in young patients presenting with sudden neurological deficit. Settings and Design : A case-control study performed in a large tertiary care government hospital. Materials and Methods : Ten milliliters of blood was collected from 51 consecutive young patients (age less than 45 years) diagnosed as ischemic stroke and 50 healthy age- and sex-matched controls. Statistical Analysis : Statistical analysis was done using Epi Info TM 6 software. Results : Overall, the risk factor profile was: Smoking (23.5%), positive family history (13.7%), hyperlipidemia (8%), and diabetes mellitus (3.6%). APL (LA and ACL) were present in 29.4% of the samples and in 4% of controls. The «SQ»P«SQ» value for ACL and LA was 0.03 and 0.02 respectively, but the maximum level of ACL was 25 GPL units only. One-fourth of the patients were smokers and one-sixth had a family history of thrombosis ( P = 0.048 and 0.036, respectively). Conclusions : APL, positive family history and smoking were significantly associated with stroke in the young. We advocate screening for APL in all young patients with stroke.


How to cite this article:
Mishra M N, Rohatgi S. Antiphospholipid antibodies in young Indian patients with stroke.J Postgrad Med 2009;55:161-164


How to cite this URL:
Mishra M N, Rohatgi S. Antiphospholipid antibodies in young Indian patients with stroke. J Postgrad Med [serial online] 2009 [cited 2020 Feb 22 ];55:161-164
Available from: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2009;volume=55;issue=3;spage=161;epage=164;aulast=Mishra;type=0


 
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