Journal of Postgraduate Medicine
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Year : 2011  |  Volume : 57  |  Issue : 3  |  Page : 184-188  

Relationship of body fat with insulin resistance and cardiometabolic risk factors among normal glucose-tolerant subjects

K Gokulakrishnan, M Deepa, F Monickaraj, V Mohan 
 Departments of Research Biochemistry, Epidemiology, Cell and Molecular Biology, Diabetology, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, IDF Centre for Education, Chennai, Tamil Nadu, India

Correspondence Address:
V Mohan
Departments of Research Biochemistry, Epidemiology, Cell and Molecular Biology, Diabetology, Madras Diabetes Research Foundation & Dr. Mohan«SQ»s Diabetes Specialities Centre, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control, IDF Centre for Education, Chennai, Tamil Nadu
India

Background : The amount of body fat, rather than the amount of excess weight, determines the health risks of obesity, type 2 diabetes mellitus, and cardiovascular disease. Aims : To look at the association of body fat percentage with cardiometabolic risk factors in subjects with normal glucose tolerance (NGT). Settings and Design : Cross-section study from the Chennai Urban Rural Epidemiology Study. Materials and Methods : Body fat was measured by Beurer body fat analyzer. Metabolic syndrome (MS) was diagnosed based on modified ATPIII guidelines. Statistical Analysis : Student«SQ»s t test or one-way ANOVA (with Tukey«SQ»s HSD) was used to compare groups for continuous variables. Results : Body mass index, waist circumference, systolic and diastolic blood pressure, HOMA IR, serum cholesterol, and LDL cholesterol increased significantly with increasing tertiles of body fat (P<0.001). There was a linear increase in the percentage of body fat with increase in number of components of MS (no metabolic abnormality: 25±11, one metabolic abnormality: 28±10, two metabolic abnormalities: 33±8, and three and more metabolic abnormalities: 35±7) (P<0.001). Regression models showed significant association of body fat with MS after adjusting for age, gender, insulin resistance, and glycated hemoglobin (Odds ratio: 1.04, 95% confidence interval: 1.04 - 1.08, P<0.001). In linear regression analysis, body fat showed a significant association with insulin resistance after adjusting for age, gender, and glycated hemoglobin (β=0.030, P<0.001). Conclusions : A significant association exists between body fat, MS, and cardiometabolic risk factors even among subjects with NGT.


How to cite this article:
Gokulakrishnan K, Deepa M, Monickaraj F, Mohan V. Relationship of body fat with insulin resistance and cardiometabolic risk factors among normal glucose-tolerant subjects.J Postgrad Med 2011;57:184-188


How to cite this URL:
Gokulakrishnan K, Deepa M, Monickaraj F, Mohan V. Relationship of body fat with insulin resistance and cardiometabolic risk factors among normal glucose-tolerant subjects. J Postgrad Med [serial online] 2011 [cited 2020 Aug 3 ];57:184-188
Available from: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2011;volume=57;issue=3;spage=184;epage=188;aulast=Gokulakrishnan;type=0


 
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