Journal of Postgraduate Medicine
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NARRATIVE REVIEW
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Year : 2014  |  Volume : 60  |  Issue : 1  |  Page : 41-45  

Role of inhaled amphotericin in allergic bronchopulmonary aspergillosis

IS Sehgal, R Agarwal 
 Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana, India

Correspondence Address:
R Agarwal
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana
India

Allergic bronchopulmonary aspergillosis (ABPA) is an immunological pulmonary disorder caused by immune reactions mounted against the ubiquitous fungus Aspergillus fumigatus. The disease clinically manifests with poorly controlled asthma, hemoptysis, systemic manifestations like fever, anorexia and weight loss, fleeting pulmonary opacities and bronchiectasis. The natural course of the disease is characterized by repeated episodes of exacerbations. Almost 30-40% of the patients require prolonged therapy, which currently consists of corticosteroids and anti-fungal azoles; both these agents have significant adverse reactions. Amphotericin B administered via the inhaled route can achieve a high concentration in the small airways with minimal systemic side-effects. Nebulized amphotericin B has been used in the management of invasive pulmonary aspergillosis. The aim of this review is to study the utility of inhaled amphotericin in ABPA.


How to cite this article:
Sehgal I S, Agarwal R. Role of inhaled amphotericin in allergic bronchopulmonary aspergillosis.J Postgrad Med 2014;60:41-45


How to cite this URL:
Sehgal I S, Agarwal R. Role of inhaled amphotericin in allergic bronchopulmonary aspergillosis. J Postgrad Med [serial online] 2014 [cited 2020 Apr 5 ];60:41-45
Available from: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2014;volume=60;issue=1;spage=41;epage=45;aulast=Sehgal;type=0


 
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