Journal of Postgraduate Medicine
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ADVERSE DRUG REACTION REPORT
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Year : 2015  |  Volume : 61  |  Issue : 2  |  Page : 110-111  

Iatrogenic nocturnal eneuresis- an overlooked side effect of anti histamines?

D Italiano1, F Italiano1, C Genovese2, RS Calabro3 
1 Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
2 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy
3 Allergology and Immunology Unit, University of Messina, Messina, Italy

Correspondence Address:
R S Calabro
Allergology and Immunology Unit, University of Messina, Messina
Italy

Nocturnal enuresis is a common disorder in childhood, but its pathophysiological mechanisms have not been fully elucidated. Iatrogenic nocturnal enuresis has been described following treatment with several psychotropic medications. Herein, we describe a 6-year-old child who experienced nocturnal enuresis during treatment with the antihistamine cetirizine. Drug rechallenge was positive. Several neurotransmitters are implicated in the pathogenesis of nocturnal enuresis, including noradrenaline, serotonin and dopamine. Antihistamine treatment may provoke functional imbalance of these pathways resulting in incontinence.


How to cite this article:
Italiano D, Italiano F, Genovese C, Calabro R S. Iatrogenic nocturnal eneuresis- an overlooked side effect of anti histamines?.J Postgrad Med 2015;61:110-111


How to cite this URL:
Italiano D, Italiano F, Genovese C, Calabro R S. Iatrogenic nocturnal eneuresis- an overlooked side effect of anti histamines?. J Postgrad Med [serial online] 2015 [cited 2019 Dec 7 ];61:110-111
Available from: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2015;volume=61;issue=2;spage=110;epage=111;aulast=Italiano;type=0


 
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