Journal of Postgraduate Medicine
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Year : 2019  |  Volume : 65  |  Issue : 1  |  Page : 18-23  

Polycystic ovary syndrome (PCOS) and kisspeptin – A Sri Lankan study

B Umayal1, SN Jayakody2, NV Chandrasekharan3, W SS Wijesundera4, CN Wijeyaratne1 
1 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Sri Jayewardenepura, Colombo, Sri Lanka
2 Department of Community Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Colombo, Sri Lanka
3 Department of Chemistry, Faculty of Science, University of Colombo, Colombo, Sri Lanka
4 Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka

Correspondence Address:
Dr. C N Wijeyaratne
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Sri Jayewardenepura, Colombo
Sri Lanka

Context: Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder affecting young women. Kisspeptins are a family of closely related peptides encoded by Kiss1 gene that controls the hypothalamic–pituitary–gonadal axis by binding to its receptor (GPR54) expressed in gonadotropin-releasing hormone (GnRH) neurons and releases GnRH. Since GnRH secretion is deregulated in PCOS, we hypothesized that dysregulated gonadotropin secretion in PCOS is reflected by kisspeptin levels. Aim: We aimed to measure serum kisspeptin levels of subjects with well-characterized PCOS versus controls and explore any correlation between kisspeptin and PCOS-related reproductive and metabolic disturbances. Materials and Methods: Consecutive women with PCOS manifesting from adolescence (n = 55) and adult controls (n = 110) were recruited. Pre-treatment baseline clinical, anthropometry, and biochemical parameters were measured in all. Serum kisspeptin and testosterone levels were determined by enzyme-linked immunosorbent assay method. Results: Serum kisspeptin and testosterone concentrations were significantly higher in women with PCOS (kisspeptin 4.873 nmol/L; testosterone 4.713 nmol/L) than controls (kisspeptin 4.127 nmol/L; testosterone 3.415 nmol/L; P < 0.05). Serum kisspeptin levels were positively associated with PCOS (odds ratio: 1.853; 95% confidence interval: 1.246–2.755; P = 0.002) in our studied population. Conclusion: Serum kisspeptin levels are higher in Sri Lankan women with PCOS manifesting from adolescence compared with controls regardless of body mass index. We propose serum kisspeptin concentration as a useful marker to recognize PCOS that manifests from adolescence.


How to cite this article:
Umayal B, Jayakody S N, Chandrasekharan N V, Wijesundera W S, Wijeyaratne C N. Polycystic ovary syndrome (PCOS) and kisspeptin – A Sri Lankan study.J Postgrad Med 2019;65:18-23


How to cite this URL:
Umayal B, Jayakody S N, Chandrasekharan N V, Wijesundera W S, Wijeyaratne C N. Polycystic ovary syndrome (PCOS) and kisspeptin – A Sri Lankan study. J Postgrad Med [serial online] 2019 [cited 2019 Jul 17 ];65:18-23
Available from: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2019;volume=65;issue=1;spage=18;epage=23;aulast=Umayal;type=0


 
Wednesday, July 17, 2019
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