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Diagrammatic representation of the direct and indirect pathways of allorecognition and the essential interaction between costimulatory ligands CD28 and B7. (Abbreviations: APC = Antigen presenting cell, MHC = Major histocompatibility complex, DCP = donor cell peptide, TCR = T cell antigen receptor).

Diagrammatic representation of the direct and indirect pathways of allorecognition and the essential interaction between costimulatory ligands CD28 and B7. (Abbreviations: APC = Antigen presenting cell, MHC = Major histocompatibility complex, DCP = donor cell peptide, TCR = T cell antigen receptor).