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Year : 1976  |  Volume : 22  |  Issue : 1  |  Page : 32-36

Levodopa in the treatment of hepatic coma due to fulminant hepatic failure

1 Department of Medicine, K.E.M Hospital, Bombay 40012, India
2 Department of Gastroenterology, K.E.M Hospital, Bombay 400012, India
3 Department of Pharmacology and Clinical Pharmacology Unit, Seth G. S. Medical College and K.E.M. Hospital, Bombay-400012, India

Correspondence Address:
J M Mehta
Department of Medicine, K.E.M Hospital, Bombay 40012
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Source of Support: None, Conflict of Interest: None

PMID: 966185

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Fifteen cases of -advancing stupor or coma due to viral hepa­titis, received levodopa intragastrically in the dose of 4 Gm. per day, in addition to the routine treatment of i.v. glucose, bowel wash -neomycin, parenteral corticosteroids and antibiotics. Liver Biopsy in all cases showed a massive liver cell necrosis. 4 patients regain­ed consciousness. 2 of these cases recovered and two others died on 15th day after starting the treatment. The rest of the patients died at different time intervals between 4th and 5th days. Although mortality in this series was high, levodopa had a definite and im­pressive awakening effect.

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Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow