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Year : 1976  |  Volume : 22  |  Issue : 2  |  Page : 66-75

Structure activity relationship of disubstituted piperazine compounds

Department of Pharmacology and Pharmacology Research Unit CSIR. Seth G. S. Medical College, Parel, Bombay 400 012, India

Correspondence Address:
N K Dadkar
Hoechst Research Centre, Mulund, Bombay 400 080.
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Source of Support: None, Conflict of Interest: None

PMID: 25964

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The various compounds belonging to the 1-4 disubstituted piperazine series exhibited the adrenolytic, hypotensive and CNS depressant activities. Appropriate substitution could also lead, to a dissociation of these pharmacological effects. It was observed that adrenolytic and CATS depressant but not the hypotensive pro­perty of these compounds was greatly susceptible to structural changes in their molecular configuration and a relationship was evident between adrenolytic and hypotensive activity as well as between CNS depressant and hypotensive activity with different structural variations.

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Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow