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Year : 1976  |  Volume : 22  |  Issue : 2  |  Page : 76-82

A comparative study of central nervous system depressant effects of some of the disubstituted piperazine compounds-part I

Department of Pharmacology and Pharmacology Research Unit C.S.I.R., Seth G. S. Medical College, Parel, Bombay 400 012, India

Correspondence Address:
N K Dadkar
Hoechst Research Centre, Mulund, Bombay 400080.
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Source of Support: None, Conflict of Interest: None

PMID: 1032679

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Comparison of central nervous system depressant activity of R-1230, R-1945 and R-1946 (disubstituted piperazine derivatives) employing various pharmacological tests revealed that R-1230 (Orthomethoxyphenyl derivative) and R-1946 (Parafluorophenyl derivative) were more potent than R-1945 (Orthof luorophenyl derivative) as CNS depressants and the CNS depression produced by these agents could be classified pharmacologically in same group as major tranquillizers like chlorpromazine. It also signified, that presence of methoxy or fluoro group within the drug molecule does not necessarily determine the activity but the position o f these groups in drug molecule is mainly responsible for determining de­gree of CNS depressant activity exerted by the compound.

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Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow