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| ARTICLE |
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| Year : 1977 | Volume
: 23
| Issue : 4 | Page : 156-160 |
Clinical trial with intravenous clonidine in treatment of severe hypertension
UG Gadgil, JD Sunavalla, IJ Pinto, UK Sheth
Department of Cardiology, K.E.M, Hospital Bombay, and Clinical Pharmacology Unit of Department of Pharmacology, Seth G. S. Medical College and K.E.M. Hospital, Parel, Bombay-400 012., India
Correspondence Address:
U G Gadgil
Department of Cardiology, K.E.M, Hospital Bombay, and Clinical Pharmacology Unit of Department of Pharmacology, Seth G. S. Medical College and K.E.M. Hospital, Parel, Bombay-400 012.
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 615261 
Thirty six patients with severe hypertension were treated with intravenous clonidine. In 67% of cases maximum response was obtained within 11 hours of administration of the drug. Average reduction in mean arterial pressure was 29%. Paradoxical rise in blood pressure was observed in some patients, immediately after clonidine administration. This could be prevented with prior administration of phentolamine intravenously. Clonidine (I.V.) supplied by two drug firms gave identical results.
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