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| ARTICLE |
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| Year : 1978 | Volume
: 24
| Issue : 1 | Page : 20-23 |
Furosemide pharmacokinetics and its relevance to ototoxicity
Nilima A Kshirsagar1, Sharadini A Dahanukar1, BP Shah2, KK Vora1, SM Karandikar1, Vidya N Acharya2, UK Sheth1
1 Department of Pharmacology, Seth G.S. Medical College, Parel, Bombay-400 012, India
2 Department of Medicine, Seth G.S. Medical College, Parel, Bombay-400 012, India
Correspondence Address:
Nilima A Kshirsagar
Department of Pharmacology, Seth G.S. Medical College, Parel, Bombay-400 012
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 731608 
Our earlier studies have demonstrated a possible pharmacokinetic explanation for the rate dependent ototoxicity of furosemide. The present study was carried out to find out possible role of plasma protein levels and drug protein binding in furosemide pharmnacokinetics and toxicity. Twenty patients with different protein patterns were given furosemide intravenously at different rates and doses. Plasma furosemide levels were fluorimetrically estimated in serial blood samples. The results indicate that dose and rate of administration and extent of binding to plasma proteins alter furosemide pharmacokinetics and the chances of toxicity are greater in hypoproteinemic patients.
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