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| ARTICLE |
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| Year : 1979 | Volume
: 25
| Issue : 1 | Page : 12-14 |
Dual action of antimuscarinic agents on the intestinal smooth muscle
SRK Acharya1, Subba Rao2
1 Department of Pharmacology. J.T.M. Medical College, Davengere 577 004, India
2 Professor of Pharmacology, Government Medical College, Bellary-583 102, India
Correspondence Address:
Subba Rao
Professor of Pharmacology, Government Medical College, Bellary-583 102
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 458737 
Propantheline, oxyphenonium, isoproponaide, epidosine, adiphenine and atropine were studied for their effect on the superfused infesting of guinea pig and rat. In small, concentrations, all drugs produced a contraction, which with increasing concentration, was Hocked. Occasionally, a contraction and a relaxation or vice versa was recorded. A partial antagonism and a potentiation on the action of acetylcholine (Ach) during recovery was observed. In very high concentrations, all drugs produced a graded contraction of intestine, except adiphenine which produced a sustained contraction. Some times, a contraction and a relaxation was also observed.
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