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Year : 1979  |  Volume : 25  |  Issue : 1  |  Page : 12-14

Dual action of antimuscarinic agents on the intestinal smooth muscle

1 Department of Pharmacology. J.T.M. Medical College, Davengere 577 004, India
2 Professor of Pharmacology, Government Medical College, Bellary-583 102, India

Correspondence Address:
Subba Rao
Professor of Pharmacology, Government Medical College, Bellary-583 102
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Source of Support: None, Conflict of Interest: None

PMID: 458737

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Propantheline, oxyphenonium, isoproponaide, epidosine, adiphe­nine and atropine were studied for their effect on the superfused infesting of guinea pig and rat. In small, concentrations, all drugs produced a contraction, which with increasing concentration, was Hocked. Occasionally, a contraction and a relaxation or vice versa was recorded. A partial antagonism and a potentiation on the action of acetylcholine (Ach) during recovery was observed. In very high concentrations, all drugs produced a graded contraction of intestine, except adiphenine which produced a sustained contraction. Some­ times, a contraction and a relaxation was also observed.

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Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow