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|Year : 1982 | Volume
| Issue : 2 | Page : 120-122
Leiomyosarcoma of penis (a case report).
Jain SS, Vohra RR, Kohli PK, Bharti
|How to cite this article:|
Jain S S, Vohra R R, Kohli P K, Bharti. Leiomyosarcoma of penis (a case report). J Postgrad Med 1982;28:120-2
Leiomyosarcoma of penis is a rare tumour. Sixteen cases of histologically proven leiomyosarcoma of penis have so far been reported.
R. L., a 55 year old male patient was admitted to the Institute hospital, with complaints of gradually increasing swelling at the tip of penis and difficulty in micturition for the last six months. Systemic examination revealed no abnormality. On local examination, glans penis was totally replaced by a firm, fungating, mass extending into the shaft [Fig. 1]. External urethral meatus was invaded by the growth. The corpus spongiosum was indurated; inguinal lymph nodes were not enlarged. Chest X-ray was normal. Wedge biopsy from the lesion revealed spindle cell sarcoma with a possibility of leiomyosarcoma.
Total amputation of penis and perineal urethrostomy was performed. Histopathology cofirmed the dignosis of leiomyosarcoma. Postoperative period was uneventful. At one and half year follow up, the patient is aymptomatic and there is no evidence of local or systemic disease.
Section showed a highly vascular tumour composed of spindle cells arranged in interlacing bundles with areas of haemorrhage and necrosis [Fig. 2]. Each cell showed enlongated eosinophilic cytoplasm, spindle shaped nucleus with open chromatin and blunted edges, and four to five mitotic figures per high power field. Interspersed with cellular areas were areas of myxoid degeneration. Tumour showed dense reticulin condensation and Masson's trichrome stain revealed mild to moderate collagen formation. Final histological diagnosis was leiomyosarcoma of the penis.
Leiomyosarcoma of penis may be superficial or deep. Superficial tumours arise from smooth muscle elements in superficial tissues of shaft of penis. Deep tumours arise from muscle fibres in corpora cavernosa, tend to invade urethra and metastasize early. The present case had a superficial tumour.
The treatment of choice is total amputation of penis. The results of local excision and radiotherapy are poor.
We thank Dr. S. P. Kaushik for allowing us to publish this case.
|1.||Greenwood, N., Fox, H. and Edwards, E. C.: Leiomyosarcoma of the penis. Cancer, 29: 481-483, 1972. |
|2.||McKenzie, P. R. and Ross, R. J. A.: Leiomyosarcoma of the penis, a report of a case. Brit. J. Surg., 56: 870-872, 1969. |
|3.||Prabhakar, B. R., Sethi, R. S., Singh, H., Tung, B. S. and Prabhakar, H.: Leiomyosarcoma of penis, Ind. J. Canter, 12: 103-106, 1975. |