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Year : 1990  |  Volume : 36  |  Issue : 1  |  Page : 16-9

Histiocytosis-X: role of histology and S-100 protein in grading the severity of disease.

Department of Pathology, Seth G. S. Medical College, Parel, Bombay, Maharashtra.

Correspondence Address:
S Y Sane
Department of Pathology, Seth G. S. Medical College, Parel, Bombay, Maharashtra.

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Source of Support: None, Conflict of Interest: None

PMID: 0002097349

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Histiocytosis-X encompasses a wide clinical spectrum from a benign localised lesion to acute generalised disease with malignant behaviour. We have reviewed material from our 18 retrospective cases comparing histological features with clinical data. Degree of positivity for S-100 protein was studied by immunoperoxidase method. Our results indicate that diagnosis of histiocytosis-X necessitates histological confirmation but grading of histological criteria and S-100 positivity do not allow prediction of severity and extent of the disease.


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Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow