Journal of Postgraduate Medicine
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 ORIGINAL ARTICLE
Year : 1991  |  Volume : 37  |  Issue : 4  |  Page : 211-5

Efficacy of 5-fluorouracil in combination with methoxyphenyl maleamic acid in murine tumors.


Bio-organic Unit, Tata Memorial Centre, Parel, Bombay.

Correspondence Address:
M A Indap
Bio-organic Unit, Tata Memorial Centre, Parel, Bombay.

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Source of Support: None, Conflict of Interest: None


PMID: 0001841970

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Combination chemotherapy studies were carried out in vivo against sarcoma 180 (ascites)(S180) and Ehrlich (ascites) carcinoma (EAC) tumours using cytotoxic drugs and methoxyphenyl maleamic acid (MPMA), an intermediate in the synthesis of pyrrolidine-nitrogen-mustards. Preliminary data have suggested that the combination of 5-fluorouracil (5-FU) and methoxyphenyl maleamic acid (MPMA) was more active than 5-FU used singly against EAC tumour. The possible therapeutic potential of this combination was further investigated in EAC tumour.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow