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| ORIGINAL ARTICLE |
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| Year : 1991 | Volume
: 37
| Issue : 4 | Page : 211-5 |
Efficacy of 5-fluorouracil in combination with methoxyphenyl maleamic acid in murine tumors.
MA Indap, RY Ambaye
Bio-organic Unit, Tata Memorial Centre, Parel, Bombay.
Correspondence Address:
M A Indap
Bio-organic Unit, Tata Memorial Centre, Parel, Bombay.
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 0001841970 
Combination chemotherapy studies were carried out in vivo against sarcoma 180 (ascites)(S180) and Ehrlich (ascites) carcinoma (EAC) tumours using cytotoxic drugs and methoxyphenyl maleamic acid (MPMA), an intermediate in the synthesis of pyrrolidine-nitrogen-mustards. Preliminary data have suggested that the combination of 5-fluorouracil (5-FU) and methoxyphenyl maleamic acid (MPMA) was more active than 5-FU used singly against EAC tumour. The possible therapeutic potential of this combination was further investigated in EAC tumour.
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