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Year : 1994  |  Volume : 40  |  Issue : 3  |  Page : 120-2

Thrombotic microangiopathy with hypertension and acute renal failure in children (a typical hemolytic uremic syndrome).

All India Institute of Medical Sciences, New Delhi., India

Correspondence Address:
U N Bhuyan
All India Institute of Medical Sciences, New Delhi.
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Source of Support: None, Conflict of Interest: None

PMID: 0008699375

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Thus I would like to conclude by saying that an idiopathic form of obliterative renal arteriopathy account for the rare presentation of severe hypertension and progressive renal failure with or without overt hemolytic anemia and thrombocytopenia in children. It can be labelled as primary malignant nephrosclerosis (NScl) or atypical HUS, based on primary thrombotic angiopathy. This, essentially intimal changes, is seen in diverse conditions and appears to result from primary endothelial injury followed by intimal exudation, thrombosis, and repair by fibrosis. Persistent or recurrence of this process form the basis of progressive obliterative arteriopathy. The result is renal ischemia and renin-angiotensin mediated hypertension. Establishment of a vicious circle would further accelerate HT and lead to end stage renal failure. Early recognition and prompt therapeutic intervention might prove beneficial.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow