Journal of Postgraduate Medicine
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Year : 1994  |  Volume : 40  |  Issue : 4  |  Page : 202-3

Tinospora cordifolia induces colony stimulating activity in serum.

Dept of Pharmacology, Seth GS Medical College, Parel, Bombay, Maharashtra.

Correspondence Address:
U M Thatte
Dept of Pharmacology, Seth GS Medical College, Parel, Bombay, Maharashtra.

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Source of Support: None, Conflict of Interest: None

PMID: 0009136239

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Tinospora cordifolia (Tc) is an Indian medicinal plant with proven immunomodulatory activity. This study was performed to elucidate its possible mechanism of action. We measured CFU-GM Cotony forming units of the granulocyte-macrophage series in serum of mice treated with Tc. We found that 10 days treatment with Tc (100 mg/ kg/d) induced a significant (p < 0.01) increase in the number of CFU-GM (255 +/- 49.32 vs 38.51 +/- 9.98) This suggests that activation of macrophages by Tc leads to increase in GM-CSF which leads to leucocytosis and improved neutrophil function.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow