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| PAPERS |
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| Year : 1994 | Volume
: 40
| Issue : 4 | Page : 204-7 |
An analysis of children with typhoid fever admitted in 1991.
CT Deshmukh, UB Nadkarni, SC Karande
Dept. of Pediatrics, KEM Hospital, Parel, Bombay, Maharashtra.
Correspondence Address:
C T Deshmukh
Dept. of Pediatrics, KEM Hospital, Parel, Bombay, Maharashtra.
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 0009136240 
In 28 children, with bacteriologically and/or serologically diagnosed typhoid fever treated at KEM Hospital, Bombay in 1991, initially one of the three recommended drugs (viz. chloramphenicol, amoxycillin or co-trimoxazole) was given for 7 days for defervescence to occur. In those who failed to respond, a second trial of therapy with one of the other two drugs was initiated, after omitting the first drug. A second failure of therapy was taken as an indication to use ciprofloxacin singly. Eventually, 18 (64.3%) cases responded to chloramphenicol or amoxycillin or co-trimoxazole. Ciprofloxacin was used in 19(35.7%) cases. the failure rate of treatment with chloramphenicol was 50%, with amoxycillin 71.4%, with co-trimoxazole 75% and 0% with ciprofloxacin. An analysis of the 28 cases revealed that apart from fever (in 100%), splenomegaly (in 82.1%) was the most important clinical pointer to diagnosis, along with absolute eosinopenia (in 71.4%). There were no major complications, except 2 cases with typhoid hepatitis who responded to choramphenicol and co-trimoxazole, respectively. Blood culture grew Salmonella typhi in 7 cases, of which 5 (72%) were multidrug resistant S. typhi. There were no characteristic clinical features to identify multi-drug resistant typhoid fever.
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