| Article Access Statistics | | | Viewed | 9240 | | | Printed | 281 | | | Emailed | 0 | | | PDF Downloaded | 126 | | | Comments | [Add] | | | Cited by others | 4 | | |
|
Click on image for details.
|
|
| CASE REPORTS |
|
|
|
| Year : 1994 | Volume
: 40
| Issue : 4 | Page : 218-9 |
Intraparenchymal schwannoma of the frontal lobe.
M Deogaonkar, A Goel, RD Nagpal, AP Desai
Dept of Neurosurgelry, KEM Hospital, Parel, Bombay, Maharashtra.
Correspondence Address:
M Deogaonkar
Dept of Neurosurgelry, KEM Hospital, Parel, Bombay, Maharashtra.
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 0009136244 
A 45 year old woman with bifrontal headaches and progressive diminution in vision over 6 months was found to have bilateral papilloedema. CT scan showed large right frontal lesion with surrounding oedema. Right basal frontotemporal craniotomy was performed to excise the multinodular, intraparenchymatous tumor. Hispathology confirmed the diagnosis of schwannoma. Post-operative course was uneventful with disappearance of pre-operative signs and symptoms.
Keywords: Brain Neoplasms, complications,diagnosis,Case Report, Female, Frontal Lobe, Headache, etiology,Human, Middle Age, Neurilemmoma, complications,diagnosis,Papilledema, etiology,Vision Disorders, etiology,
How to cite this article:
Deogaonkar M, Goel A, Nagpal R D, Desai A P. Intraparenchymal schwannoma of the frontal lobe. J Postgrad Med 1994;40:218 |
Intraparenchymatous schwannomas of the central, nervous system are rare. A literature survey revealed reports of 29 such cases[1]. Amongst these 18 were supratentorial and 11 were infratentorial in location. Three of the 18 supratentorial tumours were in the frontal lobe[2],[3],[4]. In this report the clinical presentation, radiological imaging, operative findings and histopathology of a large right frontal schwannoma are described.
A 45-year-old woman had bifrontal headaches and progressive diminution of vision for 6 months. Bilateral gross papilloedema was the only abnormal finding. Computerised tomographic (CT) scan showed a large right frontal, intensely enhancing lesion with extensive surrounding oedema [Figure - 1].
With a presumptive radiological diagnosis of a meningioma, the lesion was exposed through a right basal frontotemporal craniotomy. As expected the brain was oedematous. There were dilated emmissary veins and marked thinning of the squamous temporal bone suggesting a long-standing increase in the intracranial pressure. The lesion was firm, entirely intraparenchymatous and only moderately vascular. The multinodular tumour was excised en-masse. On histopathological examination, the tissue was seen to be composed of mixed Antoni A and B variety of schwannoma [Figure - 2]. Postoperative course was uneventful. The headaches rapidly subsided and the papilloedema cleared.
Schwannomas are benign nerve sheath tumours and account for about 8% of intracranial tumours[5]. Intraparenchymatous schwannomas, unrelated to cranial nerves are rare. Schwann cells are not indigenous to brain substance and hence histogenesis of these tumours has attracted a lot of speculation. Redekop, et al supported the theory of distorted embryogenesis. Riggs and Clary[7] postulated that the origin of these tumours is from the proliferation of Schwann cells found in the perivascular plexuses[7]. Russell and Rubenstien suggested conversion of pial cells to Schwann cells, and called this process as 'schwannosis.' Prakash et al[8] suggested misplaced myelinated nerve fibres and accompanying Schwann cells occurred in the brain as hamartomas and acted as a nidus for these tumours. Ramamurthi[9] suggested displaced neural crest cells in developing nervous system to be the origin of these tumours. A difference from multipotent mesenchymal cells has also been suggested[10]. Some cases associated with neurofibromatosis have been reported[5].
Symptoms depend on the location of these tumours. Though Russell and Rubenstein[5] stressed an early age of onset and male preponderance, this has been the exception rather than the rule. Duration of the symptoms is usually long and there are only minimal deficits at the time of presentation, despite the large tumour size. This suggests slowly growing tumours. The extensive edema around the tumour has not been a constant observation in the reported cases. Neuroradiological tests are non-specific. Even with CT and magnetic resonance imaging a preoperative diagnosis is impossible. Histopathologically these tumours need to be differentiated from microcystic meningiomas (with prominent nuclear palisading) and pilocytic astrocytomas which previously were called as ‘central schwannomas’[11]. Electron microscopy and immunohistochemistry helps in the differentiation[5]. Long-term outcome after excision is generally good[12].
The authors acknowledge with gratitude support and encouragement of Dr. Sunil K Pandya and Dr. Anil P Karapurkar. Dr. Naina Goel edited the manuscript.
| :: References | |  |
| 1. |
Sharma RR, Gurusingh LJ. Intraparenchymatous schwannoma of cerebellum. Br J Neurosurg 1993; 7:83-90.  |
| 2. | Auer Rn, Bundy J, Drake CG. Frontal lobe perivascular schwannoma. Case report. J Neurosurg 1982; 26:154-157. |
| 3. | Kasantikul V, Brown WJ, Cahan LD. Intracerebral neurilemoma. J Neurol Neurosurg Psychiatr 1971; 30:603-612. |
| 4. | Vassilouthis J, Richardson AE. Subfrontal schwannoma. Report of a case. Acta Neurochir (Wien) 1980; 53:259-266. |
| 5. | Russell DS, Rubinstien U. Pathology of Tumours of the Nervous System, 4th ed. London: Edward Arnold; 1977; 51-2:372-379. |
| 6. | Redekop G, Elisevich K, Gilbert J. Fourth ventricular schwannoma. J Neurosurg 1990; 73:771-781. |
| 7. | Riggs HE, Clary WU. A case of intramedullary sheath cell tumour of the spinal cord. Consideration of vascular nerves as a source of origin. J Neuropathol Exp Neurol 1957; 16:332-336. |
| 8. | Prakash B, Roy S, Tandon PN. Schwannoma of the brain stem: case report. J Neurosurg 1980; 53:121-123. |
| 9. | Ramamurthi B, Anguli VC, Iyer CGS. A case of intramedullary neurinoma. J Neurol Neurosug Psychiatr 1958; 21:92-94. |
| 10. | Feigin I, Ogata J. Schwann cells and peripheral myelin within human central nervous tissues: the mesenchymal character of schwann cells. J Neuropathol Exp Neurol 1971; 30:603-612. |
| 11. | Sobel RA, Michaud J. Microcystic meningioma of the falx cerebri with numerous palisading structures: an unusual histological pattern mimicking schwannoma. Acta Neuropathol 1985; 68:256. |
| 12. | Ross DA, Edwards MSB, Wilson CB. Intramedullary neurilemomas of the spinal cord: report of two cases and review of literature. Neurosurgery 1986; 19:458-464.
|
Figures
[Figure - 1], [Figure - 2]
| This article has been cited by | | 1 |
Intracranial subfrontal schwannoma treated with surgery and 3D conformal radiotherapy |
|
| Prasad D, Jalall R, Shet T | | NEUROLOGY INDIA. 2004; 52 (2): 248-250 | | [Pubmed] | | | 2 |
Frontal intraparenchymal schwannoma: an unusual presentation |
|
| Vaishya S, Sharma MS | | CHILDS NERVOUS SYSTEM. 2004; 20 (4): 247-250 | | [Pubmed] | | | 3 |
Midline cerebellar cystic schwannoma: A case report |
|
| Goel A, Bhatjiwale M, Gupta S | | NEUROLOGY INDIA. 1999; 47 (2): 127-129 | | [VIEW] | | | 4 |
Unattached intracranial extra-axial schwannoma |
|
| A Goel, R Bhayani, RD Nagpal | | British Journal of Neurosurgery. 1996; 10(4): 405-407 | | [Pubmed] | |
|
|
|
|
