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 ::  Abstract
 ::  Introduction
 ::  Case report
 ::  Discussion
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Year : 1996  |  Volume : 42  |  Issue : 3  |  Page : 82-4

Total hip arthroplasty for giant cell tumour.

Department of Orthopaedics, Seth GS Medical College, Parel, Mumbai.

Correspondence Address:
S S Kulkarni
Department of Orthopaedics, Seth GS Medical College, Parel, Mumbai.

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Source of Support: None, Conflict of Interest: None

PMID: 0009715324

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 :: Abstract 

A 32 month follow up of an uncommon case of a Giant Cell Tumour affecting the proximal end of femur is presented. Following a wide excision, the hip was reconstructed using Charnley type of low friction total hip arthroplasty. At a 32 month review, there was no recurrence and the function was good.

Keywords: Adult, Arthroplasty, Replacement, Hip, Case Report, Femoral Neoplasms, pathology,radiography,surgery,Femur Head, Femur Neck, Giant Cell Tumor of Bone, pathology,radiography,surgery,Human,

How to cite this article:
Kulkarni S S, Dogra A S, Bhosale P B. Total hip arthroplasty for giant cell tumour. J Postgrad Med 1996;42:82

How to cite this URL:
Kulkarni S S, Dogra A S, Bhosale P B. Total hip arthroplasty for giant cell tumour. J Postgrad Med [serial online] 1996 [cited 2023 Jun 9];42:82. Available from:

  ::   Introduction Top

Giant Cell Tumour (GCT) is one of the commonly encountered bone tumours in clinical practice with an incidence of upto 30.3% in parts of South India. More than 50% of these occur around the knee joint. We present here an uncommon site for occurrence of the GCT i.e. the proximal femur, and its subsequent management.

The proximal femur is an uncommon location for the occurrence of Giant Cell Tumour. Mirra[2] has reported an incidence of less than 4% of 1182 cases in this location. Schajowicz[3] in his series of 362 cases has reported only 11 cases affecting the upper end of the femur (3%).

  ::   Case report Top

A 39-year-old sedentary worker, presented to our hospital with a history of inability to walk following trivial trauma to the left hip region. The patient gave a history of constant dull ache in the left hip region since 4 months. There was no significant proximal lymphadenopathy or distal neurovascular deficit. The general examination was unremarkable. Clinically a diagnosis of pathological transcervical fracture neck femur was made. Plain roentgenograms revealed a transcervical fracture neck femur with a lytic lesion involving the head neck region. It was well demarcated with a narrow zone of transition. There was evidence of breach of the cortex posterosuperiorly [Figure - 1], [Figure - 2]. All routine hematological investigations and X-ray chest were normal. A Fine Needle Aspiration Cytology (FNAC) failed to give a definite diagnosis, revealing haemorrhagic fluid and no malignant cells.

An excisional biopsy was planned with reconstruction using the Charnley type of low friction total hip arthroplasty. On exploration through the posterolateral approach, the head-neck region demonstrated friable bony tissue containing various sized cavitations with old blood and fibrous tissue. An intralesional excision of the tumour was performed with excision of head and neck and sent for frozen section to confirm the clinical suspicion of a Giant Cell Tumour. The acetabulum and proximal femur were prepared for cementing and the margins were sent for frozen section biopsy to confirm adequacy of resection margins. The acetabular and femoral components were cemented in place and the wound was closed over a negative suction drain after meticulous haemostasis. Postoperatively the patient was made to stand with support on the fifth day and started partial weight bearing on the tenth day. The wounds healed without complications.

Microscopic evaluation of the tumour, which confirmed the diagnosis of GCT showing stromal cells with no appreciable atypism. Occasional stromal cells showed large nuclei with abundant giant cells. The stroma showed little evidence of fibrous or collagenous differentiation. (Grade 1)[4].

At a 32 months follow-up the wounds had healed by primary intention and there was no evidence of recurrence locally. The patient was pain-free and satisfied with a left hip range of motion of:

Flexion - 0? - 90? Abduction - 0? - 30?

Int. Rotation - 0? - 20? Ext. Rotation - 0? - 20?

There was a limb length discrepancy of 1 cm, which was treated with an appropriate heel raise. The patient returned to his daily activities and was walking full weight bearing, with a mild Trendelenberg lurch.

  ::   Discussion Top

The reconstruction of the hip joint following excision for tumours is essential for maintenance of stability and normalisation of gait patterns. The options after excision include a Girdlestone type of excisional arthroplasty, hemiarthroplasty or total hip arthroplasty. The instability and shortening caused by an excisional arthroplasty was not acceptable to our patient. Poor results of hemiarthroplasty in young patients have been well documented in literature[5]. Good long-term follow-up of cemented arthroplasty in young patients has recently been documented[6]. Also the use of bone cement has been shown to decrease the incidence of local recurrence in GCT[7]. The use of methymethacrylate leads to the formation of a 2 mm osteolytic zone surrounding it which is surrounded by sclerotic rim. Lysis or failed development of the sclerotic zone adjacent to the lytic zone is suspicious of recurrence, which was not seen in our case. Though histo-pathological and radiological staging exist they do not correlate clinically with the incidence of recurrence. Our case was Grade 1 (Jaffe) histo-pathologically and at a 32 month follow-up there has been no recurrence.

 :: References Top

1. Reddy CR, Rao PS, Rajakumari K. Giant cell tumours of bone in South India. J Bone Joint Surg 1974; 56-A: 617.  Back to cited text no. 1    
2.Mirra JM. Giant Cell Tumours. Mirra JM, editor. Bone Tumours, Clinical Radiologic and Pathologic correlations. Vol. 2. Philadelphia: Lea and Febiger; 1989, pp 942.  Back to cited text no. 2    
3.Schajowicz F. Giant Cell Tumour (Osteoclastoma). Schajowiez F, editor. Tumours and Tumour like Lesions of Bone and Joints, New York: Springer - Verlag; 1981, pp 205.  Back to cited text no. 3    
4.Jaffe HL, Lichtenstein L, Portis RB. GCT of bone, Its Pathological Appearance, Grading, Supposed Variants and Treatment. Arch Pathology 1940; 30:993.  Back to cited text no. 4    
5.Gebhard JS, Amstutz HC, Zinar DM, Dorey FJ. A comparison of Total Hip Arthroplasty and Hemi-arthroplasty for the treatment of acute fractures of the femoral neck. Clin Otthop 1992; 282:123.  Back to cited text no. 5    
6.Joshi AB, Porter ML, Trail IA, Hunt LP, Murphy JCM, Hardinge K. Long-term results of Charnley Low-Friction Arthroplasty in young patients. J Bone Joint Surg 1993; 75-13:616.  Back to cited text no. 6    
7.Carrasco HC, Murray JA. Giant Cell Tumours. In Bone Tumours, Evaluation and Treatment, Lewis MM (Guest Ed). Orth Clin N America, Vol 20, No 3, 1989, pp 395.  Back to cited text no. 7    
8.Patterson H, Rydholm, Persson B. Early radiologic detection of local recurrence after curettage and acrylic cementation of giant cell tumours. Eur J Radiol 1986; 6:1.   Back to cited text no. 8    


[Figure - 1], [Figure - 2], [Figure - 3]

This article has been cited by
1 Diagnostic and therapeutic problems of giant cell tumor in the proximal femur
Sakayama K, Sugawara Y, Kidani T, et al.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
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